| Gene Symbol | Pla2g2a |
|---|---|
| Entrez Gene | 18780 |
| Alt Symbol | EF, Mom1, Pla2, sPLA2, sPla2-IIA |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | phospholipase A2, group IIA (platelets, synovial fluid) |
| Other Description | GIIC sPLA2|enhancing factor|group IIA phospholipase A2|modifier of Min1|non-pancreatic secreted type II phospholipase A2|phosphatidylcholine 2-acylhydrolase 2A|phospholipase A2 group IIa|phospholipase A2, membrane associated|secretory group II phospholipase A2 |
| Swissprots | Q60871 P31482 |
| Accessions | AAC52252 AHB62392 P31482 AK131857 BC045156 AAH45156 CB933893 U28244 AAB06315 U32359 AAB60494 X74266 CAA52325 NM_001082531 NP_001076000 NR_002926 NM_011108 |
| Function | May play a role in cell proliferation, by increasing the binding of EGF to the cells and thereby modulating its action. In doing so, this isozyme binds to a membrane-associated receptor distinct from the EGF receptor and which could be a heparan- sulfate proteoglycan located on the cell membrane. |
| Subcellular Location | Membrane; Peripheral membrane protein. |
| Tissue Specificity | Mainly in the Paneth cells adjacent to the stem population in the small intestines. Also expressed in regenerating liver and hyperplastic esophageal epithelium. |
| Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |