CD46

Gene Symbol	CD46
Entrez Gene	4179
Alt Symbol	AHUS2, MCP, MIC10, TLX, TRA2.10
Species	Human
Gene Type	protein-coding
Description	CD46 molecule, complement regulatory protein
Other Description	CD46 antigen, complement regulatory protein|antigen identified by monoclonal antibody TRA-2-10|complement membrane cofactor protein|measles virus receptor|membrane cofactor protein|membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)|trophoblast leucocyte common antigen|trophoblast leukocyte common antigen|trophoblast-lymphocyte cross-reactive antigen
Swissprots	Q15429 Q5VWT2 Q5VWS9 Q7Z3R5 A0T1T0 Q5VWT1 Q9NNW2 A0T1T2 Q5VWS6 A0T1T1 Q6N0A1 Q9NNW4 Q5HY94 Q9NNW3 Q9UCJ4 Q53GV9 Q5VWT0 Q5VWS7 Q5VWS8 P15529
Accessions	AAD13968 AAW82433 ABI96986 EAW93463 EAW93464 EAW93465 EAW93466 EAW93467 EAW93468 EAW93469 EAW93470 EAW93471 EAW93472 EAW93473 EAW93474 EAW93475 EAW93476 EAW93477 P15529 A18585 CAA01400 AF209712 AAF73844 AF209713 AAF73845 AF209714 AAF73846 AI589224 AK129560 AK222822 BAD96542 AK291227 BAF83916 AK296819 BAG59392 AU131238 BC007046 BC026273 BC030594 AAH30594 BX537451 CAD97694 BX640613 CAE45719 BX649050 CAI45983 D84105 BAA12224 DB078198 DQ890901 ABM81827 DQ894054 ABM84980 EF076055 ABK81635 EF076056 ABK81636 EF076057 ABK81637 EF076058 ABK81638 M58050 AAA62833 S51940 AAB24802 X59405 X59406 X59407 X59408 X59409 X59410 Y00651 CAA68675 Y07713 CAA68985 XM_011509563 XP_011507865 XM_011509564 XP_011507866 NM_002389 NP_002380 NM_153826 NP_722548 NM_172350 NP_758860 NM_172351 NP_758861 NM_172352 NP_758862 NM_172353 NP_758863 NM_172359 NP_758869 NM_172361 NP_758871 NM_172354 NM_172355 NM_172356 NM_172357 NM_172358 NM_172360
Function	Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. {ECO:0000269|PubMed:10843656, ECO:0000269|PubMed:12540904}.
Subcellular Location	Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane {ECO:0000269|PubMed:12112588, ECO:0000269|PubMed:14597734, ECO:0000269|PubMed:15307194}; Single- pass type I membrane protein {ECO:0000269|PubMed:12112588, ECO:0000269|PubMed:14597734, ECO:0000269|PubMed:15307194}. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.
Tissue Specificity	Expressed by all cells except erythrocytes.
Top Pathways	Complement and coagulation cascades, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD46 full length protein - ab132954 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CD46 peptide - ab72835 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CD46 protein fragment - ab140724 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

Human CD46 protein fragment - ab151345 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source HEK 293 cells Species Human

Human CD46 protein fragment - ab174047 from Abcam Category Protein Prices $442.00 Sizes 50 µg Source HEK 293 cells Species Human

CD46 Antibody Blocking Peptide - LS-E7590 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CD46 Protein - H00004179-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CD46 Partial Recombinant Protein - H00004179-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

Recombinant Human CD46 Protein - NBP2-22754 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

CD46 Recombinant Protein - H00004179-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

CD46-Antibody-C-term-Blocking-Peptide - BP4785b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CD46 His tag protein - orb84325 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source Human Species Human

Human CD46 protein - orb49282 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human CD46 protein - orb191081 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E. coli Species Human

CAPG protein - 30R-1439 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

CD46 protein (His tag) - 80R-2740 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human MCP Protein - abx067989 from Abbexa Category Protein Source E.coli Species Human

CD46 / MCP (35-313, His-tag) - AR50860PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CD46 / MCP (35-313, His-tag) - AR50860PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CD46 / MCP - H00004179-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD46 / MCP - H00004179-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD46 / MCP - H00004179-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD46 / MCP - H00004179-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD46 / MCP - H00004179-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD46, 35-313aa, Human, His tag, E.coli - 01-P2036 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Search more