Mapkap1

Gene Symbol Mapkap1
Entrez Gene 227743
Alt Symbol AI591529, D230039K05Rik, Sin1
Species Mouse
Gene Type protein-coding
Description mitogen-activated protein kinase associated protein 1
Other Description SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mitogen activated protein kinase associated protein 1|mitogen-activated protein kinase 2-associated protein 1|stress-activated map kinase-interacting protein 1|target of rapamycin complex 2 subunit MAPKAP1
Swissprots Q8R2N9 A2AN74 A2AR16 A2AR13 Q80UY4 Q8BKH7 A2AN72 Q8BMV5
Accessions EDL08613 EDL08614 Q8BKH7 AK027932 BAC25671 AK042154 AK052045 BAC34838 AK132263 BAE21066 AK148428 AK178100 AK191438 AK217607 BB852269 BC012681 BC027377 AAH27377 BC031579 AAH31579 BC043296 AAH43296 BC048870 AAH48870 BC090644 AAH90644 BC096618 AAH96618 XM_006497975 XP_006498038 XM_006497978 XP_006498041 XM_006497980 XP_006498043 XM_006497982 XP_006498045 XM_006497983 XP_006498046 XM_011239082 XP_011237384 XM_011239083 XP_011237385 XM_011239084 XP_011237386 XM_011239085 XP_011237387 NM_001290625 NP_001277554 NM_001290626 NP_001277555 NM_177345 NP_796319
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Uniquitously expresseed, with highest levels in testis, kidney and liver. Present in renal tubule cells (at protein level). {ECO:0000269|PubMed:17054722}.

Recombinant Mouse Target of rapamycin complex 2 subunit MAPKAP1(Mapkap1) - CSB-YP806861MO CSB-EP806861MO CSB-BP806861MO CSB-MP806861MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Target of rapamycin complex 2 subunit MAPKAP1 (Mapkap1), Recombinant Protein - MBS1417050 from MyBioSource

Category Protein
Prices $1,310.00, $1,310.00, $1,530.00, $1,530.00, $2,160.00, $2,160.00, $2,625.00, $2,625.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Sin1, Peptide - MBS843763 from MyBioSource

Category Peptide
Prices $165.00
Sizes 50 µg

Recombinant Mouse MAPKAP1 Protein - MAPKAP1-9543M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse
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