| Gene Symbol |
Mapkap1
|
| Entrez Gene |
227743
|
| Alt Symbol |
AI591529, D230039K05Rik, Sin1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase associated protein 1
|
| Other Description |
SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mitogen activated protein kinase associated protein 1|mitogen-activated protein kinase 2-associated protein 1|stress-activated map kinase-interacting protein 1|target of rapamycin complex 2 subunit MAPKAP1
|
| Swissprots |
Q8R2N9 A2AN74 A2AR16 A2AR13 Q80UY4 Q8BKH7 A2AN72 Q8BMV5
|
| Accessions |
EDL08613 EDL08614 Q8BKH7 AK027932 BAC25671 AK042154 AK052045 BAC34838 AK132263 BAE21066 AK148428 AK178100 AK191438 AK217607 BB852269 BC012681 BC027377 AAH27377 BC031579 AAH31579 BC043296 AAH43296 BC048870 AAH48870 BC090644 AAH90644 BC096618 AAH96618 XM_006497975 XP_006498038 XM_006497978 XP_006498041 XM_006497980 XP_006498043 XM_006497982 XP_006498045 XM_006497983 XP_006498046 XM_011239082 XP_011237384 XM_011239083 XP_011237385 XM_011239084 XP_011237386 XM_011239085 XP_011237387 NM_001290625 NP_001277554 NM_001290626 NP_001277555 NM_177345 NP_796319
|
| Function |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Uniquitously expresseed, with highest levels in testis, kidney and liver. Present in renal tubule cells (at protein level). {ECO:0000269|PubMed:17054722}.
|