Gene Symbol | Nat8l |
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Entrez Gene | 269642 |
Alt Symbol | 1110038O08Rik, Shati |
Species | Mouse |
Gene Type | protein-coding |
Description | N-acetyltransferase 8-like |
Other Description | N-acetylaspartate synthetase|N-acetyltransferase 8-like protein|NAA synthetase|protein Shati |
Swissprots | Q6DID6 Q8K065 Q3UH43 Q3UGX3 |
Accessions | EDL37443 Q3UGX3 AK004167 AK147307 BAE27836 AK147594 BAE28014 AK147703 BAE28084 BC034068 AAH34068 BC075616 AAH75616 DQ174094 ABA54615 NM_001001985 NP_001001985 |
Function | Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. {ECO:0000269|PubMed:19014384, ECO:0000269|PubMed:19807691, ECO:0000269|PubMed:20385109, ECO:0000269|PubMed:20643647}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane; Single-pass membrane protein. |
Tissue Specificity | Expressed in brain, kidney, liver and spleen. In brain, present in neurons but not in astrocytes (at protein level). Expressed in brain, thymus and spleen. {ECO:0000269|PubMed:17626222, ECO:0000269|PubMed:19807691, ECO:0000269|PubMed:20385109}. |
Top Pathways | Alanine, aspartate and glutamate metabolism |
NAT-8L CRISPR/Cas9 KO Plasmid (m) - sc-435363 from Santa Cruz Biotechnology
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NAT-8L HDR Plasmid (m) - sc-435363-HDR from Santa Cruz Biotechnology
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NAT-8L Double Nickase Plasmid (m) - sc-435363-NIC from Santa Cruz Biotechnology
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NAT-8L Double Nickase Plasmid (m2) - sc-435363-NIC-2 from Santa Cruz Biotechnology
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NAT-8L CRISPR Activation Plasmid (m) - sc-435363-ACT from Santa Cruz Biotechnology
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NAT-8L CRISPR Activation Plasmid (m2) - sc-435363-ACT-2 from Santa Cruz Biotechnology
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NAT-8L Lentiviral Activation Particles (m) - sc-435363-LAC from Santa Cruz Biotechnology
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NAT-8L Lentiviral Activation Particles (m2) - sc-435363-LAC-2 from Santa Cruz Biotechnology
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NAT-8L siRNA (m) - sc-149844 from Santa Cruz Biotechnology
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NAT-8L shRNA Plasmid (m) - sc-149844-SH from Santa Cruz Biotechnology
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NAT-8L shRNA (m) Lentiviral Particles - sc-149844-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU065691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN36217 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36217 from Sigma-Aldrich
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NAT8L siRNA (Mouse) - CRN4085 from Cohesion Biosciences
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shRNA set against Mouse NAT8L (NM_001001985.3) - SHH349544 from Creative biogene
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Mouse NAT8L siRNA - orb293560 from Biorbyt
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NAT8L shRNA Plasmid (Mouse) - CHN4085 from Cohesion Biosciences
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NAT8L miRNA 3'UTR clone - MiUTR1M-07512 from Creative biogene
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