Gene Symbol | Nat8l |
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Entrez Gene | 269642 |
Alt Symbol | 1110038O08Rik, Shati |
Species | Mouse |
Gene Type | protein-coding |
Description | N-acetyltransferase 8-like |
Other Description | N-acetylaspartate synthetase|N-acetyltransferase 8-like protein|NAA synthetase|protein Shati |
Swissprots | Q6DID6 Q8K065 Q3UH43 Q3UGX3 |
Accessions | EDL37443 Q3UGX3 AK004167 AK147307 BAE27836 AK147594 BAE28014 AK147703 BAE28084 BC034068 AAH34068 BC075616 AAH75616 DQ174094 ABA54615 NM_001001985 NP_001001985 |
Function | Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. {ECO:0000269|PubMed:19014384, ECO:0000269|PubMed:19807691, ECO:0000269|PubMed:20385109, ECO:0000269|PubMed:20643647}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane; Single-pass membrane protein. |
Tissue Specificity | Expressed in brain, kidney, liver and spleen. In brain, present in neurons but not in astrocytes (at protein level). Expressed in brain, thymus and spleen. {ECO:0000269|PubMed:17626222, ECO:0000269|PubMed:19807691, ECO:0000269|PubMed:20385109}. |
Top Pathways | Alanine, aspartate and glutamate metabolism |
N-acetylaspartate synthetase, Nat8l, Mouse, ELISA Kit - E4070m from ARP American Research Products
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N-acetyltransferase 8-like (GCN5-related, putative) , ELISA Kit - MBS2602929 from MyBioSource
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Mouse N-acetylaspartate synthetase ELISA Kit - abx255122 from Abbexa
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Mouse N-acetylaspartate synthetase ELISA Kit - EKE54505 from Biomatik
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Nat8l - EKM1548 from Nordic BioSite
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Mouse Nat8l ELISA Kit - E060950 from Biobool
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NAT8L ELISA Kit (Mouse) (OKEH03540) - OKEH03540 from Aviva Systems Biology
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Mouse N-acetylaspartate synthetase ELISA Kit - EK4624 from Signalway Antibody
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N-acetylaspartate synthetase, ELISA Kit - MBS2880775 from MyBioSource
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N-acetylaspartate synthetase, ELISA Kit - MBS9428450 from MyBioSource
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