CPE

Gene Symbol CPE
Entrez Gene 1363
Alt Symbol -
Species Human
Gene Type protein-coding
Description carboxypeptidase E
Other Description CPH|carboxypeptidase H|cobalt-stimulated chromaffin granule carboxypeptidase|enkephalin convertase|insulin granule-associated carboxypeptidase|prohormone-processing carboxypeptidase
Swissprots Q9UIU9 P16870 D3DP33 A8K4N1 B4DFN4 B3KR42
Accessions BAA86053 EAX04817 EAX04818 EAX04819 P16870 AI340177 AK090962 BAG52254 AK127165 BAG54445 AK290996 BAF83685 AK294175 BAG57495 BC033866 AAH33866 BC053612 AAH53612 BM271829 DQ893322 ABM84248 DQ896637 ABM87636 X51405 CAA35767 NM_001873 NP_001864
Function Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Subcellular Location Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250}.
Tissue Specificity Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas. {ECO:0000269|PubMed:21285511}.
Top Pathways Type I diabetes mellitus

CPE CRISPR/Cas9 KO Plasmid (h) - sc-404429 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CPE HDR Plasmid (h) - sc-404429-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CPE Double Nickase Plasmid (h) - sc-404429-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CPE Double Nickase Plasmid (h2) - sc-404429-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CPE CRISPR Activation Plasmid (h) - sc-404429-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CPE CRISPR Activation Plasmid (h2) - sc-404429-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CPE Lentiviral Activation Particles (h) - sc-404429-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CPE Lentiviral Activation Particles (h2) - sc-404429-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CPE siRNA (h) - sc-45378 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CPE shRNA Plasmid (h) - sc-45378-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CPE shRNA (h) Lentiviral Particles - sc-45378-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU084581 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6498 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6498 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06149 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06149

CPE siRNA (Human) - CRH0953 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CPE - MBS828704 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CPE (NM_001873.2) - SHH268597 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CPE(NM_001873.2) - SHG195563 from Creative biogene

Category siRNA
Species Reactivities Human

Human CPE siRNA - orb261455 from Biorbyt

Category siRNA
Species Reactivities Human

CPE shRNA Plasmid (Human) - CHH0953 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CPE miRNA 3'UTR clone - MiUTR1H-02387 from Creative biogene

Species Reactivities Human
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