CPE

Gene Symbol	CPE
Entrez Gene	1363
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	carboxypeptidase E
Other Description	CPH|carboxypeptidase H|cobalt-stimulated chromaffin granule carboxypeptidase|enkephalin convertase|insulin granule-associated carboxypeptidase|prohormone-processing carboxypeptidase
Swissprots	Q9UIU9 P16870 D3DP33 A8K4N1 B4DFN4 B3KR42
Accessions	BAA86053 EAX04817 EAX04818 EAX04819 P16870 AI340177 AK090962 BAG52254 AK127165 BAG54445 AK290996 BAF83685 AK294175 BAG57495 BC033866 AAH33866 BC053612 AAH53612 BM271829 DQ893322 ABM84248 DQ896637 ABM87636 X51405 CAA35767 NM_001873 NP_001864
Function	Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Subcellular Location	Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250}.
Tissue Specificity	Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas. {ECO:0000269|PubMed:21285511}.
Top Pathways	Type I diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Carboxypeptidase H protein fragment - ab167757 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

Active mouse Carboxypeptidase H full length protein - ab169054 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Mouse

Human Carboxypeptidase H full length protein - ab139787 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

Human Carboxypeptidase H protein fragment - ab116901 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Carboxypeptidase E / CPE Antibody Blocking Peptide - LS-E21378 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Carboxypeptidase E / CPE Antibody Blocking Peptide - LS-E9160 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Carboxypeptidase E/CPE Partial Recombinant Protein - H00001363-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Carboxypeptidase E/CPE Protein - NBP2-22733 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

CPE-Antibody-C-term-Blocking-Peptide - BP7657b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Carboxypeptidase E/CPE, CF - 3587-ZN-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Arg42-Ser453, with a C-terminal 6-His tag

Human CPE Fc tag protein - orb82921 from Biorbyt Category Protein Prices $323.00, $527.00 Sizes 10 μg, 20 μg Source Human Species Human

Human CPE protein - orb180202 from Biorbyt Category Protein Prices $366.00, $706.00, $2,525.00, $3,579.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human CPE protein - orb191406 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source Escherichia Coli. Species Human

Human CPE His tag protein - orb83348 from Biorbyt Category Protein Prices $417.00, $638.00 Sizes 10 μg, 20 μg Source Human Species Human

Carboxypeptidase E Blocking Peptide - 33R-3440 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CPE protein (His tag) - 80R-2657 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Carboxypeptidase E Blocking Peptide - abx062455 from Abbexa Category Peptide Species Human, Mouse, Rat

Human Carboxypeptidase E Protein - abx065714 from Abbexa Category Protein Source E.coli Species Human

Human Carboxypeptidase E Protein - abx065716 from Abbexa Category Protein Source E.coli Species Human

Carboxypeptidase E (43-476, His-tag) - AR50777PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Carboxypeptidase E (43-476, His-tag) - AR50777PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Carboxypeptidase E - H00001363-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Carboxypeptidase E - H00001363-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Carboxypeptidase E (CPE), Human - 20-9050 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Human

CPE, 43-476aa Human, His tag, E.coli - 01-P1953 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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