| Gene Symbol |
Trpv4
|
| Entrez Gene |
66026
|
| Alt Symbol |
Otrpc4, Vroac
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily V, member 4
|
| Other Description |
VR-OAC|osm-9-like TRP channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential cation channel subfamily V member 4|transient receptor potential cation channel, subfamily 5, member 4|vanilloid receptor-related osmotically activated channel (Vroac)|vanilloid receptor-related osmotically-activated channel
|
| Swissprots |
Q9ERZ8
|
| Accessions |
EDM13932 EDM13933 Q9ERZ8 AF263521 AAG28027 XM_006249466 XP_006249528 NM_023970 NP_076460
|
| Function |
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13- didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. {ECO:0000250}.
|
| Tissue Specificity |
Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. {ECO:0000269|PubMed:11081638}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels
|