Trpv4

Gene Symbol Trpv4
Entrez Gene 66026
Alt Symbol Otrpc4, Vroac
Species Rat
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 4
Other Description VR-OAC|osm-9-like TRP channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential cation channel subfamily V member 4|transient receptor potential cation channel, subfamily 5, member 4|vanilloid receptor-related osmotically activated channel (Vroac)|vanilloid receptor-related osmotically-activated channel
Swissprots Q9ERZ8
Accessions EDM13932 EDM13933 Q9ERZ8 AF263521 AAG28027 XM_006249466 XP_006249528 NM_023970 NP_076460
Function Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13- didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. {ECO:0000250}.
Tissue Specificity Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. {ECO:0000269|PubMed:11081638}.
Top Pathways Inflammatory mediator regulation of TRP channels

Transient receptor potential cation channel subfamily V member 4 (TRPV4), Rat, ELISA Kit - CSB-EL025096RA from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

transient receptor potential cation channel, subfamily V, member 4, ELISA Kit - MBS909593 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of rat TRPV4 is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 23.5 pg/ml -1500 pg/ml.

transient receptor potential cation channel, subfamily V, member 4, ELISA Kit - MBS9310828 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat Transient receptor potential cation channel subfamily V member 4(TRPV4) ELISA kit - CSB-EL025096RA from Cusabio

Category ELISA Kit
Sensitivity 5.8 pg/ml.
Range 23.5 pg/ml-1500 pg/ml

Rat Transient receptor potential cation channel subfamily V member 4 (TRPV4) ELISA Kit - EKC39808 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 5.8 pg/ml
Range 23.5 pg/ml-1500 pg/ml

Rat Trpv4 ELISA Kit - E101380 from Biobool

Category ELISA Kit

TRPV4 ELISA Kit (Rat) (OKCA01942) - OKCA01942 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 5.8 pg/mL
Range 23.5 - 1,500 pg/mL

Rat TRPV4 ELISA Kit - orb411165 from Biorbyt

Category ELISA Kit
Sensitivity 5.8 pg/ml.
Range 23.5 pg/ml-1500 pg/ml
Search more