| Gene Symbol |
ACSL6
|
| Entrez Gene |
23305
|
| Alt Symbol |
ACS2, FACL6, LACS 6, LACS2, LACS5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA synthetase long-chain family member 6
|
| Other Description |
fatty-acid-Coenzyme A ligase, long-chain 6|long fatty acyl-CoA synthetase 2|long-chain-fatty-acid--CoA ligase 6
|
| Swissprots |
Q9UKU0 J3KPG3 O94924 Q86TN7 Q108N0 O95829 Q4G191 Q108M9
|
| Accessions |
EAW62355 EAW62356 EAW62357 EAW62358 EAW62359 EAW62360 Q9UKU0 AB020644 BAA74860 AF102845 AF129166 AAD47199 AK122702 BAG53676 AK294291 BAG57574 AK314452 BAG37060 AW952652 BC026161 AAH26161 BC047453 AAH47453 BI464352 BI545119 BI548729 BM992189 DA200154 DA801862 DB461818 DQ083030 AAZ30713 DQ083031 AAZ30714 DQ655980 JF432422 ADZ15639 NM_001009185 NP_001009185 NM_001205247 NP_001192176 NM_001205248 NP_001192177 NM_001205250 NP_001192179 NM_001205251 NP_001192180 NM_015256 NP_056071
|
| Function |
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain. {ECO:0000269|PubMed:10548543}.
|
| Top Pathways |
Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation
|