Gene Symbol | PLA2G10 |
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Entrez Gene | 8399 |
Alt Symbol | GXPLA2, GXSPLA2, SPLA2 |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A2, group X |
Other Description | GX sPLA2|group 10 secretory phospholipase A2|group X secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 10|sPLA2-X |
Swissprots | O15496 Q14DU3 Q6NT23 |
Accessions | CCQ43219 EAW85104 O15496 BC069539 AAH69539 BC106731 AAI06732 BC106732 AAI06733 BC111804 AAI11805 CR456885 CAG33166 U95301 AAB64410 XM_011522695 XP_011520997 XM_011522696 XP_011520998 XM_011522697 XP_011520999 XM_011522698 XP_011521000 XM_011546724 XP_011545026 XM_011546725 XP_011545027 XM_011546726 XP_011545028 XM_011546727 XP_011545029 NM_003561 NP_003552 |
Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. |
Subcellular Location | Secreted. |
Tissue Specificity | Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon. |
Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |
group X sPLA 2 CRISPR/Cas9 KO Plasmid (h) - sc-416644 from Santa Cruz Biotechnology
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group X sPLA 2 HDR Plasmid (h) - sc-416644-HDR from Santa Cruz Biotechnology
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group X sPLA 2 Double Nickase Plasmid (h) - sc-416644-NIC from Santa Cruz Biotechnology
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group X sPLA 2 Double Nickase Plasmid (h2) - sc-416644-NIC-2 from Santa Cruz Biotechnology
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group X sPLA 2 CRISPR Activation Plasmid (h) - sc-416644-ACT from Santa Cruz Biotechnology
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group X sPLA 2 CRISPR Activation Plasmid (h2) - sc-416644-ACT-2 from Santa Cruz Biotechnology
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group X sPLA 2 Lentiviral Activation Particles (h) - sc-416644-LAC from Santa Cruz Biotechnology
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group X sPLA 2 Lentiviral Activation Particles (h2) - sc-416644-LAC-2 from Santa Cruz Biotechnology
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group X sPLA 2 siRNA (h) - sc-43821 from Santa Cruz Biotechnology
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group X sPLA 2 shRNA Plasmid (h) - sc-43821-SH from Santa Cruz Biotechnology
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group X sPLA 2 shRNA (h) Lentiviral Particles - sc-43821-V from Santa Cruz Biotechnology
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Phospholipase A2 X RNAi - H00008399-R01 from Novus Biologicals
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Phospholipase A2 X RNAi - H00008399-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN16882 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16882 from Sigma-Aldrich
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PLA2G10 siRNA (Human) - CRH5504 from Cohesion Biosciences
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shRNA set against Human PLA2G10 (NM_003561.1) - SHH376664 from Creative biogene
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shRNA set against Human PLA2G10(NM_003561.1) - SHR118644 from Creative biogene
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Human PLA2G10 siRNA - orb266006 from Biorbyt
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PLA2G10 shRNA Plasmid (Human) - CHH5504 from Cohesion Biosciences
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PLA2G10 miRNA 3'UTR clone - MiUTR1H-07953 from Creative biogene
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