| Gene Symbol | SERPING1 |
|---|---|
| Entrez Gene | 710 |
| Alt Symbol | C1IN, C1INH, C1NH, HAE1, HAE2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 |
| Other Description | C1 esterase inhibitor|C1-inhibiting factor|complement component 1 inhibitor|plasma protease C1 inhibitor|serine/cysteine proteinase inhibitor clade G member 1|serpin G1 |
| Swissprots | Q7Z455 Q9UCF9 B4E1F0 B2R6L5 Q96FE0 A6NMU0 B4E1H2 Q9UC49 Q59EI5 A8KAI9 Q16304 Q547W3 P05155 |
| Accessions | AAA53096 AAB33044 AAM21515 AAQ19269 AAW69393 CAA30314 CAA38358 EAW73762 EAW73763 EAW73764 P05155 AB209826 BAD93063 AK293054 BAF85743 AK303809 BAG64762 AK303840 BAG64784 AK312626 BAG35512 AL703442 AY732485 AAV33124 AY732486 AAV33125 BC011171 AAH11171 BQ183346 BT006966 AAP35612 DQ891799 ABM82725 DQ894982 ABM85908 GU727623 ADU87625 M13203 AAA51849 M13656 AAB59387 M13690 AAA35613 M14036 AAA51848 X07577 CAA30469 NM_000062 NP_000053 NM_001032295 NP_001027466 |
| Function | Activation of the C1 complex is under control of the C1- inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. {ECO:0000269|PubMed:8495195}. |
| Subcellular Location | Secreted. |
| Top Pathways | Complement and coagulation cascades, Pertussis |