Gene Symbol | Ace2 |
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Entrez Gene | 70008 |
Alt Symbol | 2010305L05Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 |
Other Description | ACE-related carboxypeptidase|angiotensin I converting enzyme 2|angiotensin-converting enzyme 2 |
Swissprots | Q8R0I0 Q99N70 Q99N71 |
Accessions | EDL40761 Q8R0I0 AB053181 BAB40431 AB053182 BAB40432 AI115946 AK008530 BAB25723 AK135357 BAE22502 AK141604 BAE24759 BC026801 AAH26801 BY722909 EF408739 ABN80105 EF408740 ABN80106 GQ262785 ACT66269 NM_001130513 NP_001123985 NM_027286 NP_081562 |
Function | Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury. {ECO:0000269|PubMed:12075344, ECO:0000269|PubMed:12967627, ECO:0000269|PubMed:16001071}. |
Subcellular Location | Processed angiotensin-converting enzyme 2: Secreted {ECO:0000250}. |
Tissue Specificity | Expressed in heart, kidney and forebrain (at protein level). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on vascular endothelial and airway epithelial cells. {ECO:0000269|PubMed:12487024, ECO:0000269|PubMed:15949646, ECO:0000269|PubMed:16001071}. |
Top Pathways | Protein digestion and absorption, Renin-angiotensin system |
Recombinant Mouse ACE-2, CF - 3437-ZN-010 from R&D Systems
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Mouse Angiotensin I Converting Enzyme 2 protein - orb84117 from Biorbyt
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Mouse Angiotensin I Converting Enzyme 2 protein - orb84116 from Biorbyt
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Recombinant Mouse Ace2, His-tagged - Ace2-761M from Creative Biomart
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Recombinant Mouse ACE2, FLAG-tagged - ACE2-69M from Creative Biomart
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Recombinant Mouse Ace2, Fc-His tagged - Ace2-1183M from Creative Biomart
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Recombinant Mouse Ace2, His tagged - Ace2-1184M from Creative Biomart
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ACE2/ACEH - PN201218 from Elabscience
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Mouse ACE2 / Angiotensin-Converting Enzyme 2 Protein (His Tag) - 50249-M08H-10 from Sino Biological
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Mouse ACE2 / Angiotensin-Converting Enzyme 2 Protein (His & Fc Tag) - 50249-M03H-10 from Sino Biological
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Recombinant Angiotensin I Converting Enzyme 2 (ACE2) - RPB886Mu01 from Cloud-clone
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Recombinant Angiotensin I Converting Enzyme 2 (ACE2) - RPB886Mu02 from Cloud-clone
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Recombinant Mouse Angiotensin-converting enzyme 2(Ace2) - CSB-YP851244MO CSB-EP851244MO CSB-BP851244MO CSB-MP851244MO from Cusabio
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Recombinant Mouse ACE-2 Protein, CF - 3437-ZN from R&D Systems
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Angiotensin I Converting Enzyme 2 (ACE2) - RPU140283 from Biomatik
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Angiotensin-converting enzyme 2, 18-740aa, Mouse, His tag, Baculovirus - ATGP3288 from ATGen
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Angiotensin-converting enzyme 2(Ace2) , Recombinant Protein - MBS1359799 from MyBioSource
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Recombinant Mouse ACE2 / Angiotensin-Converting Enzyme 2 Protein (His tag) - PKSM040779 from Elabscience
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Recombinant Mouse ACE2 / Angiotensin-Converting Enzyme 2 Protein (His & Fc tag) - PKSM040780 from Elabscience
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Angiotensin-converting enzyme 2 - PAT-83287-1 from Nordic BioSite
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Angiotensin-converting enzyme 2 - PAT-83287-2 from Nordic BioSite
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Recombinant Angiotensin I Converting Enzyme 2 (ACE2) - RPU40283 from Biomatik
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ACE2 Recombinant Protein (OPCD01026) - OPCD01026 from Aviva Systems Biology
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Mouse ACE2 / Angiotensin-Converting Enzyme 2 Protein (His & Fc Tag) - 50249-M03H from ABclonal
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Mouse ACE2 / Angiotensin-Converting Enzyme 2 Protein (His Tag) - 50249-M08H from ABclonal
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