IFIT2

Gene Symbol	IFIT2
Entrez Gene	3433
Alt Symbol	G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42
Species	Human
Gene Type	protein-coding
Description	interferon-induced protein with tetratricopeptide repeats 2
Other Description	Interferon, alpha-inducible protein (MW 54kD)|interferon-induced 54 kDa protein|interferon-induced protein 54
Swissprots	P09913 Q5T767
Accessions	AAA59191 CAA30438 EAW50145 P09913 AA143609 AA765174 AF026944 AK300431 BAG62157 AK312831 BC005987 AAH05987 BC032839 AAH32839 DA631671 EB387611 NM_001547 NP_001538
Function	IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. {ECO:0000269|PubMed:21190939}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21190939}. Endoplasmic reticulum {ECO:0000269|PubMed:21190939}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IFIT2 CRISPR/Cas9 KO Plasmid (h) - sc-403830 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IFIT2 HDR Plasmid (h) - sc-403830-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IFIT2 Double Nickase Plasmid (h) - sc-403830-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IFIT2 Double Nickase Plasmid (h2) - sc-403830-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IFIT2 CRISPR Activation Plasmid (h) - sc-403830-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IFIT2 CRISPR Activation Plasmid (h2) - sc-403830-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IFIT2 Lentiviral Activation Particles (h) - sc-403830-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IFIT2 Lentiviral Activation Particles (h2) - sc-403830-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IFIT2 siRNA (h) - sc-75324 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IFIT2 shRNA Plasmid (h) - sc-75324-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IFIT2 shRNA (h) Lentiviral Particles - sc-75324-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU117631 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU117591 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10467 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10467 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10618 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr10618

IFIT2 siRNA (Human) - CRH2325 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IFIT2 - MBS8228355 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human IFIT2 (NM_001547.4) - SHH316921 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IFIT2(NM_001547.4) - SHL165990 from Creative biogene Category siRNA Species Reactivities Human

IFIT2 CRISPR/Cas9 KO Plasmid (h2) - sc-403830-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IFIT2 HDR Plasmid (h2) - sc-403830-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Human IFIT2 siRNA - orb262827 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IFIT2 shRNA Plasmid (Human) - CHH2325 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

IFIT2 miRNA 3'UTR clone - MiUTR1H-04805 from Creative biogene Species Reactivities Human

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