| Gene Symbol |
IFIT2
|
| Entrez Gene |
3433
|
| Alt Symbol |
G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon-induced protein with tetratricopeptide repeats 2
|
| Other Description |
Interferon, alpha-inducible protein (MW 54kD)|interferon-induced 54 kDa protein|interferon-induced protein 54
|
| Swissprots |
P09913 Q5T767
|
| Accessions |
AAA59191 CAA30438 EAW50145 P09913 AA143609 AA765174 AF026944 AK300431 BAG62157 AK312831 BC005987 AAH05987 BC032839 AAH32839 DA631671 EB387611 NM_001547 NP_001538
|
| Function |
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. {ECO:0000269|PubMed:21190939}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21190939}. Endoplasmic reticulum {ECO:0000269|PubMed:21190939}.
|