Gene Symbol | MC4R |
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Entrez Gene | 4160 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | melanocortin 4 receptor |
Other Description | MC4-R|melanocortin receptor 4 |
Swissprots | Q16317 B2RAC3 P32245 Q3MIJ6 |
Accessions | AAA35791 AAB33341 AAO92061 ABK35297 ABK35298 ABK35299 ABK35300 AFV34058 AFV34059 AFV34060 AFV34061 AFV34062 EAW63105 P32245 AK314130 BAG36820 BC069172 AAH69172 BC101802 AAI01803 BC111992 AAI11993 DA362673 NM_005912 NP_005903 |
Function | Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). {ECO:0000269|PubMed:12646665}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Brain, placental, and gut tissues. |
Top Pathways | Neuroactive ligand-receptor interaction |
MC4-R CRISPR/Cas9 KO Plasmid (h) - sc-417769 from Santa Cruz Biotechnology
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MC4-R HDR Plasmid (h) - sc-417769-HDR from Santa Cruz Biotechnology
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MC4-R Double Nickase Plasmid (h) - sc-417769-NIC from Santa Cruz Biotechnology
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MC4-R Double Nickase Plasmid (h2) - sc-417769-NIC-2 from Santa Cruz Biotechnology
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MC4-R CRISPR Activation Plasmid (h) - sc-417769-ACT from Santa Cruz Biotechnology
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MC4-R CRISPR Activation Plasmid (h2) - sc-417769-ACT-2 from Santa Cruz Biotechnology
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MC4-R Lentiviral Activation Particles (h) - sc-417769-LAC from Santa Cruz Biotechnology
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MC4-R Lentiviral Activation Particles (h2) - sc-417769-LAC-2 from Santa Cruz Biotechnology
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MC4-R siRNA (h) - sc-35873 from Santa Cruz Biotechnology
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MC4-R shRNA Plasmid (h) - sc-35873-SH from Santa Cruz Biotechnology
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MC4-R shRNA (h) Lentiviral Particles - sc-35873-V from Santa Cruz Biotechnology
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Melanocortin-4 R RNAi - H00004160-R02 from Novus Biologicals
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MISSION® esiRNA - EHU006521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2313 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2313 from Sigma-Aldrich
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MC4R siRNA (Human) - CRH2832 from Cohesion Biosciences
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shRNA set against Human MC4R (NM_005912.2) - SHH339063 from Creative biogene
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shRNA set against Human MC4R(NM_005912.2) - SHH180371 from Creative biogene
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MC4R shRNA Plasmid (Human) - CHH2832 from Cohesion Biosciences
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MC4R miRNA 3'UTR clone - MiUTR1H-06151 from Creative biogene
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