| Gene Symbol |
YBX2
|
| Entrez Gene |
51087
|
| Alt Symbol |
CONTRIN, CSDA3, DBPC, MSY2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Y box binding protein 2
|
| Other Description |
DNA-binding protein C|MSY2 homolog|Y-box-binding protein 2|germ cell specific Y-box binding protein|germ cell-specific Y-box-binding protein
|
| Swissprots |
Q8N4P0 D3DTP1 Q9Y2T7
|
| Accessions |
EAW90223 EAW90224 EAW90225 Q9Y2T7 AB208818 BAD92055 AF096834 AAD30662 AI805280 AK092747 AK315035 BAG37519 BC033800 AAH33800 BC047760 AAH47760 DB065912 NM_015982 NP_057066
|
| Function |
Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16479255}. Nucleus {ECO:0000269|PubMed:16479255}.
|
| Tissue Specificity |
Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level). {ECO:0000269|PubMed:10100484, ECO:0000269|PubMed:16479255}.
|
