| Gene Symbol |
EIF2S2
|
| Entrez Gene |
8894
|
| Alt Symbol |
EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
|
| Other Description |
eukaryotic translation initiation factor 2 subunit 2|eukaryotic translation initiation factor 2 subunit beta|protein phosphatase 1, regulatory subunit 67
|
| Swissprots |
Q9BVU0 P20042 Q9UJE4
|
| Accessions |
AAD19864 EAW76284 EAW76285 EAW76286 P20042 AB208966 BAD92203 AB451237 BAG70051 AB451362 BAG70176 AK313025 BAG35860 BC000461 AAH00461 BC000934 AAH00934 BC007888 AAH07888 BC070316 BC107588 AAI07589 BT009795 AAP88797 BX648379 CR456734 CAG33015 DQ891005 ABM81931 DQ894184 ABM85110 M29536 AAA52383 XM_005260605 XP_005260662 NM_003908 NP_003899
|
| Function |
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
|
| Top Pathways |
RNA transport
|