AGRP

Gene Symbol AGRP
Entrez Gene 181
Alt Symbol AGRT, ART, ASIP2
Species Human
Gene Type protein-coding
Description agouti related neuropeptide
Other Description agouti related protein homolog|agouti-related protein
Swissprots Q2TBD9 O15459 O00253
Accessions AAK96256 AAL09457 ABC88473 DAA06531 EAW83137 O00253 BC110443 AAI10444 U88063 AAB52240 U89485 AAB68621 XM_011522927 XP_011521229 NM_001138 NP_001129
Function Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. {ECO:0000250, ECO:0000269|PubMed:10371151, ECO:0000269|PubMed:11145747, ECO:0000269|PubMed:15927146, ECO:0000269|PubMed:17041250, ECO:0000269|PubMed:9892020}.
Subcellular Location Secreted {ECO:0000269|PubMed:15927146}. Golgi apparatus lumen {ECO:0000269|PubMed:15927146}.
Tissue Specificity Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Top Pathways Adipocytokine signaling pathway

AGRP (H-53) - sc-50299 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AGRP (H-53): sc-50299. Immunoperoxidase staining of formalin fixed, paraffin-embedded human esophagus tissue showing cytoplasmic staining of squamous epithelial cells.

AGRP (T-20) - sc-18631 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-AGRP antibody - ab113481 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab113481 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab113481 at 10µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-AGRP antibody - ab199126 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling AGRP with ab199126 at 1/20 dilution.

Anti-AGRP antibody - ab86956 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
IHC image of AGRP staining in human Hippocampus FFPE section, performed on a BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab86956, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX

Anti-AGRP antibody - ab32882 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of PFA-perfused frozen Human hypothalamus tissue, staining AGRP with ab32882 at 0.05 &microg/ml. Antigen retrieval was performed by heat mediation in a citrate buffer (pH 6).

Anti-AGRP antibody [MM0085-32B12] - ab89114 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0085-32B12

Anti-AGRP Antibody (C-Terminus) - LS-C3577 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody - LS-C122623 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-AGRP Antibody (C-Terminus) - LS-C3576 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody - LS-C63824 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody (aa119-132) - LS-C54458 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-AGRP Antibody (clone 82806) - LS-C125012 from LifeSpan Bioscience

Prices $620.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 82806

Anti-AGRP Antibody (Biotin) - LS-C125015 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-AGRP Antibody (clone 82815) - LS-C125014 from LifeSpan Bioscience

Prices $620.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 82815

Anti-AGRP Antibody - LS-C149879 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-AGRP Antibody - LS-C150318 from LifeSpan Bioscience

Prices $305.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody - LS-C150146 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-AGRP Antibody (aa82-132) - LS-C190463 from LifeSpan Bioscience

Prices $605.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody (aa71-132) - LS-C190462 from LifeSpan Bioscience

Prices $740.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody (aa82-131) - LS-C190464 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody (aa83-132) - LS-C190465 from LifeSpan Bioscience

Prices $740.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody (aa82-131) - LS-C190466 from LifeSpan Bioscience

Prices $605.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody - LS-C178500 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AGRP Antibody (aa34-130) - LS-C292684 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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