TAF2
| Gene Symbol | TAF2 |
|---|---|
| Entrez Gene | 6873 |
| Alt Symbol | CIF150, MRT40, TAF2B, TAFII150 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa |
| Other Description | 150 kDa cofactor of initiator function|RNA polymerase II TBP-associated factor subunit B|TAF(II)150|TATA box binding protein (TBP)-associated factor, RNA polymerase II, B, 150kD|TBP-associated factor 150 kDa|cofactor of initiator function, 150kD subunit|transcription initiation factor TFIID 150 kDa subunit|transcription initiation factor TFIID subunit 2 |
| Swissprots | O43487 Q86WW7 O43604 B2RE82 O60668 Q8IWK4 Q6P1X5 |
| Accessions | EAW91991 EAW91992 EAW91993 Q6P1X5 AF026445 AAC02966 AF040701 AAC68502 AF057694 AAC13540 AK001618 BAG50950 AK001909 BAG50991 AK316592 BAG38179 AL137601 CAB70836 AU098502 BC008473 BC018010 BC035673 AAH35673 BC037262 BC047732 AAH47732 BC064830 AAH64830 BC146379 AAI46380 XM_006716621 XP_006716684 XM_011517259 XP_011515561 XM_011517260 XP_011515562 XM_011517261 XP_011515563 XM_011517262 XP_011515564 NM_003184 NP_003175 |
| Function | Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. {ECO:0000269|PubMed:9418870, ECO:0000269|PubMed:9774672}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:9774672}. |
| Tissue Specificity | Expressed in all tissues tested. {ECO:0000269|PubMed:9774672}. |
| Top Pathways | Basal transcription factors |
TAF II p150 CRISPR/Cas9 KO Plasmid (h) - sc-407643 from Santa Cruz Biotechnology
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TAF II p150 HDR Plasmid (h) - sc-407643-HDR from Santa Cruz Biotechnology
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TAF II p150 Double Nickase Plasmid (h) - sc-407643-NIC from Santa Cruz Biotechnology
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TAF II p150 Double Nickase Plasmid (h2) - sc-407643-NIC-2 from Santa Cruz Biotechnology
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TAF II p150 CRISPR Activation Plasmid (h) - sc-407643-ACT from Santa Cruz Biotechnology
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TAF II p150 CRISPR Activation Plasmid (h2) - sc-407643-ACT-2 from Santa Cruz Biotechnology
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TAF II p150 Lentiviral Activation Particles (h) - sc-407643-LAC from Santa Cruz Biotechnology
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TAF II p150 Lentiviral Activation Particles (h2) - sc-407643-LAC-2 from Santa Cruz Biotechnology
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TAF II p150 siRNA (h) - sc-77487 from Santa Cruz Biotechnology
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TAF II p150 shRNA Plasmid (h) - sc-77487-SH from Santa Cruz Biotechnology
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TAF II p150 shRNA (h) Lentiviral Particles - sc-77487-V from Santa Cruz Biotechnology
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TAF2 RNAi - H00006873-R01 from Novus Biologicals
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MISSION® esiRNA - EHU049261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20970 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20970 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08697 from Sigma-Aldrich
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TAF2 siRNA (Human) - CRH4702 from Cohesion Biosciences
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TAF2 - MBS8211546 from MyBioSource
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shRNA set against Human TAF2 (NM_003184.3) - SHH422690 from Creative biogene
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shRNA set against Human TAF2(NM_003184.3) - SHL054666 from Creative biogene
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TAF2 shRNA Plasmid (Human) - CHH4702 from Cohesion Biosciences
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TAF2 miRNA 3'UTR clone - MiUTR1H-10155 from Creative biogene
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