| Gene Symbol |
TAF2
|
| Entrez Gene |
6873
|
| Alt Symbol |
CIF150, MRT40, TAF2B, TAFII150
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
|
| Other Description |
150 kDa cofactor of initiator function|RNA polymerase II TBP-associated factor subunit B|TAF(II)150|TATA box binding protein (TBP)-associated factor, RNA polymerase II, B, 150kD|TBP-associated factor 150 kDa|cofactor of initiator function, 150kD subunit|transcription initiation factor TFIID 150 kDa subunit|transcription initiation factor TFIID subunit 2
|
| Swissprots |
O43487 Q86WW7 O43604 B2RE82 O60668 Q8IWK4 Q6P1X5
|
| Accessions |
EAW91991 EAW91992 EAW91993 Q6P1X5 AF026445 AAC02966 AF040701 AAC68502 AF057694 AAC13540 AK001618 BAG50950 AK001909 BAG50991 AK316592 BAG38179 AL137601 CAB70836 AU098502 BC008473 BC018010 BC035673 AAH35673 BC037262 BC047732 AAH47732 BC064830 AAH64830 BC146379 AAI46380 XM_006716621 XP_006716684 XM_011517259 XP_011515561 XM_011517260 XP_011515562 XM_011517261 XP_011515563 XM_011517262 XP_011515564 NM_003184 NP_003175
|
| Function |
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. {ECO:0000269|PubMed:9418870, ECO:0000269|PubMed:9774672}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9774672}.
|
| Tissue Specificity |
Expressed in all tissues tested. {ECO:0000269|PubMed:9774672}.
|
| Top Pathways |
Basal transcription factors
|