| Gene Symbol |
FRZB
|
| Entrez Gene |
2487
|
| Alt Symbol |
FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, OS1, SFRP3, SRFP3, hFIZ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
frizzled-related protein
|
| Other Description |
frezzled|frizzled homolog-related|frizzled-related protein 1|sFRP-3|secreted frizzled-related protein 3
|
| Swissprots |
Q92765 O00181 Q99686
|
| Accessions |
AAX93117 AAY24241 ADL14515 EAX10958 Q92765 AK130009 AK312741 BAG35611 AU117730 BC027855 AAH27855 BE549700 BF058813 BT019883 AAV38686 DQ890944 ABM81870 DQ894106 ABM85032 U24163 AAC50736 U68057 AAC51217 U91903 AAB51298 NM_001463 NP_001454
|
| Function |
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Tissue Specificity |
Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver.
|