TP53BP2

Gene Symbol	TP53BP2
Entrez Gene	7159
Alt Symbol	53BP2, ASPP2, BBP, P53BP2, PPP1R13A
Species	Human
Gene Type	protein-coding
Description	tumor protein p53 binding protein 2
Other Description	BCL2-binding protein|apoptosis-stimulating of p53 protein 2|apoptosis-stimulating protein of p53, 2|renal carcinoma antigen NY-REN-51|tumor protein p53 binding protein, 2|tumor suppressor p53-binding protein 2
Swissprots	Q96KQ3 Q86X75 Q13625 Q12892 B4DG66
Accessions	EAW93247 EAW93248 Q13625 AA961496 AI042183 AJ318888 CAC83012 AK294432 BAG57677 AK294654 BAH11835 AK294964 BAG58037 AK295378 BAG58337 AK316016 BAH14387 AK316103 BAH14474 AL357233 BC040247 AAH40247 BC046150 AAH46150 BC058918 AAH58918 BX425756 U09582 AAA21597 U58334 AAC50557 XM_011544267 XP_011542569 XM_011544268 XP_011542570 XM_011544269 XP_011542571 XM_011544270 XP_011542572 NM_001031685 NP_001026855 NM_005426 NP_005417
Function	Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Subcellular Location	Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
Tissue Specificity	Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. {ECO:0000269|PubMed:10498867, ECO:0000269|PubMed:10631318, ECO:0000269|PubMed:11684014}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human 53BP2/ASPP2 peptide - ab36003 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human 53BP2/ASPP2 protein fragment - ab152759 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

TP53BP2 / ASPP2 Antibody Blocking Peptide - LS-E4113 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human 53BP2 Protein - H00007159-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TP53BP2-Antibody-N-term-Blocking-Peptide - BP16353a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TP53BP2 Blocking Peptide - 33R-9157 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TP53BP2 - H00007159-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TP53BP2 - H00007159-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Apoptosis-stimulating of p53 protein 2(TP53BP2) ,partial - CSB-YP622676HU CSB-EP622676HU CSB-BP622676HU CSB-MP622676HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TP53BP2 Protein - abx164196 from Abbexa Category Protein Species Human, Mouse, Rat

Apoptosis-stimulating of p53 protein 2(TP53BP2) ,partial, Recombinant Protein - MBS1484185 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

TP53BP2 fusion protein - Ag25165 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

53BP2 Protein - NBP1-90324PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

TP53BP2 Peptide, Human - M34GP16455H from Creative Peptides Category Peptide Source Synthetic. Species Human

TP53BP2 fusion protein - Ag24907 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

53BP2 Recombinant Protein Antigen - NBP2-58677PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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