| Gene Symbol |
TP53BP2
|
| Entrez Gene |
7159
|
| Alt Symbol |
53BP2, ASPP2, BBP, P53BP2, PPP1R13A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor protein p53 binding protein 2
|
| Other Description |
BCL2-binding protein|apoptosis-stimulating of p53 protein 2|apoptosis-stimulating protein of p53, 2|renal carcinoma antigen NY-REN-51|tumor protein p53 binding protein, 2|tumor suppressor p53-binding protein 2
|
| Swissprots |
Q96KQ3 Q86X75 Q13625 Q12892 B4DG66
|
| Accessions |
EAW93247 EAW93248 Q13625 AA961496 AI042183 AJ318888 CAC83012 AK294432 BAG57677 AK294654 BAH11835 AK294964 BAG58037 AK295378 BAG58337 AK316016 BAH14387 AK316103 BAH14474 AL357233 BC040247 AAH40247 BC046150 AAH46150 BC058918 AAH58918 BX425756 U09582 AAA21597 U58334 AAC50557 XM_011544267 XP_011542569 XM_011544268 XP_011542570 XM_011544269 XP_011542571 XM_011544270 XP_011542572 NM_001031685 NP_001026855 NM_005426 NP_005417
|
| Function |
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
|
| Subcellular Location |
Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
|
| Tissue Specificity |
Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. {ECO:0000269|PubMed:10498867, ECO:0000269|PubMed:10631318, ECO:0000269|PubMed:11684014}.
|
| Top Pathways |
Hippo signaling pathway
|