Gene Symbol |
TNNI1
|
Entrez Gene |
7135
|
Alt Symbol |
SSTNI, TNN1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
troponin I type 1 (skeletal, slow)
|
Other Description |
troponin I, slow skeletal muscle|troponin I, slow-twitch isoform
|
Swissprots |
Q86T57 Q6FGW1 P19237 Q96DT9 Q6FGS7 Q6ICU2 A8MSJ0 A6NEH3 Q659A5
|
Accessions |
AAC14461 EAW91365 EAW91366 EAW91367 EAW91368 P19237 AJ315823 CAC44240 AK123965 BAG53988 AK223588 BAD97308 AK311896 BAG34837 AL831820 CAD38534 AL831975 CAH56221 AL832006 AM392810 CAL37688 BC012600 AAH12600 BC012601 AAH12601 BI825503 BX510903 CAD91135 CR450301 CAG29297 CR541996 CAG46793 CR542030 CAG46827 DQ892818 ABM83744 DQ896064 ABM87063 J04760 AAA61228 NM_003281 NP_003272
|
Function |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
|
Tissue Specificity |
Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes. {ECO:0000269|PubMed:2365354, ECO:0000269|PubMed:8144655}.
|