ARF6

Gene Symbol ARF6
Entrez Gene 382
Alt Symbol -
Species Human
Gene Type protein-coding
Description ADP-ribosylation factor 6
Other Description -
Swissprots P62330 Q6FGZ2
Accessions AAP50257 EAW65740 P62330 AF047432 AAC39877 AF493885 AAM12599 AK313790 BAG36527 AL117621 AL121163 BC002952 BC008918 AAH08918 BC030291 BM838197 BT019868 AAV38671 CR541939 CAG46737 CR541964 CAG46762 DA217686 M57763 AAA90928 NM_001663 NP_001654
Function GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000269|PubMed:11266366, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:18400762, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:7589240}.
Subcellular Location Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell projection, filopodium membrane; Lipid-anchor. Midbody {ECO:0000250}. Cytoplasm {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=Distributed throughout the cytoplasm during metaphase. Transiently detected at the ingressing cleavage furrow during mitotic cytokinesis. Recruited to the midbody at later stages of cytokinesis; this requires interaction with KIF23 (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. {ECO:0000250}.
Tissue Specificity Ubiquitous, with higher levels in heart, substantia nigra, and kidney. {ECO:0000269|PubMed:14659046}.
Top Pathways Fc gamma R-mediated phagocytosis, Endocytosis

ARF6 CRISPR/Cas9 KO Plasmid (h) - sc-400799 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARF6 HDR Plasmid (h) - sc-400799-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARF6 Double Nickase Plasmid (h) - sc-400799-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARF6 Double Nickase Plasmid (h2) - sc-400799-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARF6 CRISPR Activation Plasmid (h) - sc-400799-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARF6 CRISPR Activation Plasmid (h2) - sc-400799-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARF6 Lentiviral Activation Particles (h) - sc-400799-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARF6 Lentiviral Activation Particles (h2) - sc-400799-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARF6 siRNA (h) - sc-43619 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARF6 shRNA Plasmid (h) - sc-43619-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARF6 shRNA (h) Lentiviral Particles - sc-43619-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARF6 RNAi - H00000382-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU118271 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU137641 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3391 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3391 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11912 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11912

ARF6 siRNA (Human) - CRH0273 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARF6 - MBS8236587 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARF6 CRISPR/Cas9 KO Plasmid (h2) - sc-400799-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARF6 HDR Plasmid (h2) - sc-400799-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human ARF6 (NM_001663.3) - SHH239134 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ARF6(NM_001663.3) - SHG068599 from Creative biogene

Category siRNA
Species Reactivities Human

Human ARF6 siRNA - orb260775 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARF6 shRNA Plasmid (Human) - CHH0273 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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