ARF6

Gene Symbol	ARF6
Entrez Gene	382
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	ADP-ribosylation factor 6
Other Description	-
Swissprots	P62330 Q6FGZ2
Accessions	AAP50257 EAW65740 P62330 AF047432 AAC39877 AF493885 AAM12599 AK313790 BAG36527 AL117621 AL121163 BC002952 BC008918 AAH08918 BC030291 BM838197 BT019868 AAV38671 CR541939 CAG46737 CR541964 CAG46762 DA217686 M57763 AAA90928 NM_001663 NP_001654
Function	GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000269|PubMed:11266366, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:18400762, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:7589240}.
Subcellular Location	Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell projection, filopodium membrane; Lipid-anchor. Midbody {ECO:0000250}. Cytoplasm {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=Distributed throughout the cytoplasm during metaphase. Transiently detected at the ingressing cleavage furrow during mitotic cytokinesis. Recruited to the midbody at later stages of cytokinesis; this requires interaction with KIF23 (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. {ECO:0000250}.
Tissue Specificity	Ubiquitous, with higher levels in heart, substantia nigra, and kidney. {ECO:0000269|PubMed:14659046}.
Top Pathways	Fc gamma R-mediated phagocytosis, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ARF6 peptide - ab86625 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human ARF6 (deletion K12, mutated Q67 L) full length protein - ab176615 from Abcam Category Protein Prices $378.00 Sizes 10 µg Source E. coli Species Human

Human ARF6 full length protein - ab102025 from Abcam Category Protein Prices $235.00, $866.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human ARF6 protein fragment - ab176671 from Abcam Category Protein Prices $378.00 Sizes 100 µg Source E. coli Species Human

ARF6 Antibody Blocking Peptide - LS-E19666 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ARF6 Recombinant Protein - H00000382-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ARF6 Protein - NBP1-49459 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

ARF6-Antibody-C-term-Blocking-Peptide - BP6814b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ARF6 Protein (OPPA02598) - OPPA02598 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg

Human ARF6 protein - orb244029 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human ARF6 protein - orb167910 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

ARF6 Blocking Peptide - 33R-7882 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ARF6 protein (His tag) - 80R-1563 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

ARF6 Blocking Peptide - abx062267 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Pig, Zebrafish

ARF6 (1-175, His-tag) - AR09742PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

ARF6 (1-175, His-tag) - AR09742PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

ADP-ribosylation factor 6 (ARF6) - H00000382-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ADP-ribosylation factor 6 (ARF6) - H00000382-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ADP-Ribosylation Factor 6, Human Recombinant - 228-12754-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human ADP-Ribosylation Factor 6 - 228-12754-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human ADP-Ribosylation Factor 6 - 228-12754-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

ARF6, 1-175aa, Human, His tag, E.coli - 01-1894-6 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ARF6 Peptide - 7699P from ProSci Category Peptide Species Human

ARF6 fusion protein - Ag12642 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

ARF6 Human - PRPS-039 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

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