PPP4C

Gene Symbol	PPP4C
Entrez Gene	5531
Alt Symbol	PP-X, PP4, PP4C, PPH3, PPP4, PPX
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 4, catalytic subunit
Other Description	protein phosphatase 4 (formerly X), catalytic subunit|protein phosphatase X, catalytic subunit|serine/threonine-protein phosphatase 4 catalytic subunit
Swissprots	P60510 P33172
Accessions	EAW79928 EAW79929 EAW79930 EAW79931 P60510 AA765831 AF097996 AAC96318 AL519181 BC001416 AAH01416 BG705710 BG706310 BG741669 BQ220878 BT019746 AAV38551 DQ891947 ABM82873 DQ895134 ABM86060 X70218 CAA49753 XM_006721061 XP_006721124 NM_001303503 NP_001290432 NM_001303504 NP_001290433 NM_001303506 NP_001290435 NM_001303507 NP_001290436 NM_002720 NP_002711
Function	Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. {ECO:0000250, ECO:0000269|PubMed:11698396, ECO:0000269|
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Top Pathways	Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PPP4C full length protein - ab114692 from Abcam Category Protein Source Wheat germ Species Human

Human PPP4C full length protein - ab171584 from Abcam Category Protein Source E. coli Species Human

Human PPP4C protein fragment - ab114693 from Abcam Category Protein Source Wheat germ Species Human

PPP4C Antibody Blocking Peptide - LS-E2679 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP4C Antibody Blocking Peptide - LS-E21411 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP4C Antibody Blocking Peptide - LS-E27073 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP4C Recombinant Protein - H00005531-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 10 ug 25 ug Species Human

PPP4C Partial Recombinant Protein - H00005531-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PPP4C Protein - NBP2-23383 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

PPP4C-Antibody-Center-Blocking-peptide - BP13756c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPP4C blocking peptide - GTX88412-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Rat, Rabbit

PPP4C Blocking Peptide - 33R-9365 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPP4C protein (His tag) - 80R-2994 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

PPP4C Peptide - AC21-1895-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PPP4C (1-307, His-tag) - AR51112PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PPP4C (1-307, His-tag) - AR51112PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PPP4C - H00005531-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

PPP4C - H00005531-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PPP4C - H00005531-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PPP4C, 1-307aa, Human, His tag, E.coli - 01-P2288 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

PPP4C Peptide - 42-003P from ProSci Category Peptide Species Human

PPP4C fusion protein - ag0356 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PPP4C, 1-307aa, Human, His tag, E.coli - GWB-ATG471 from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Species Human

Recombinant Human PPP4C - PPP4C-27640TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PPP4C - PPP4C-29539TH from Creative Biomart Category Protein Source Wheat germ

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