PPP4C

Gene Symbol PPP4C
Entrez Gene 5531
Alt Symbol PP-X, PP4, PP4C, PPH3, PPP4, PPX
Species Human
Gene Type protein-coding
Description protein phosphatase 4, catalytic subunit
Other Description protein phosphatase 4 (formerly X), catalytic subunit|protein phosphatase X, catalytic subunit|serine/threonine-protein phosphatase 4 catalytic subunit
Swissprots P60510 P33172
Accessions EAW79928 EAW79929 EAW79930 EAW79931 P60510 AA765831 AF097996 AAC96318 AL519181 BC001416 AAH01416 BG705710 BG706310 BG741669 BQ220878 BT019746 AAV38551 DQ891947 ABM82873 DQ895134 ABM86060 X70218 CAA49753 XM_006721061 XP_006721124 NM_001303503 NP_001290432 NM_001303504 NP_001290433 NM_001303506 NP_001290435 NM_001303507 NP_001290436 NM_002720 NP_002711
Function Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. {ECO:0000250, ECO:0000269|PubMed:11698396, ECO:0000269|
Subcellular Location Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Top Pathways Glucagon signaling pathway

PPX (C-6) - sc-374106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PPX (C-6): sc-374106. Western blot analysis of PPX expression in 293T (A) and HeLa (B) whole cell lysates.

PPX (FL-40) - sc-50439 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PPX (C-18) - sc-6118 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PPX (C-18): sc-6118. Western blot analysis of PPX expression in HeLa (A), JAR (B) and NTERA-2 cl.D1 (C) whole cell lysates.

Anti-PPP4C antibody - ab151273 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
All lanes : Anti-PPP4C antibody (ab151273) at 1/1000 dilutionLane 1 : Hela cell lysatesLane 2 : 293 cell lysatesLane 3 : Jurkat cell lysates

Anti-PPP4C antibody [2] - ab101021 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2
Anti-PPP4C antibody [2] (ab101021) at 1/1000 dilution + FCM7 whole cell lysate

Anti-PPP4C antibody - N-terminal - ab71324 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Analysis of human breast carcinoma tissue with 1:50 ab71324. DAB staining.

Anti-PPP4C Antibody (Internal) - LS-C26550 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PPP4C Antibody (aa294-307) - LS-C75218 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4C Antibody (C-Terminus) - LS-C91591 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PPP4C Antibody - LS-C178822 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-PPP4C Antibody (aa159-189, AP) - LS-C266976 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4C Antibody (aa159-189, APC) - LS-C266977 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4C Antibody (aa159-189, Biotin) - LS-C266978 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4C Antibody (aa159-189, FITC) - LS-C266979 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4C Antibody (aa159-189, Azide-free, HRP) - LS-C266981 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4C Antibody (aa159-189, PE) - LS-C266982 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4C Antibody (aa159-189) - LS-C324250 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4C Antibody - LS-C192872 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of various cell lines, using PPP4C antibody.

Anti-PPP4C Antibody (clone 1E8) - LS-C197972 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E8
Detection limit for recombinant GST tagged PPP4C is 0.3 ng/ml as a capture antibody.

Anti-PPP4C Antibody (C-Terminus) - LS-C112208 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PPP4C antibody LS-C112208 Western blot of Fetal Muscle lysate.

Anti-PPP4C Antibody (aa1-50) - LS-C287684 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PPP4C by Immunohistochemistry. Samples: FFPE serial sections of human prostate carcinoma. Antibody: Affinity purified rabbit anti-PPP4C used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.

Anti-PPP4C Antibody (aa1-50) - LS-C286424 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse PPP4C by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-PPP4C used at a dilution of 1:100.

Anti-PPP4C Antibody IHC-plus™ - LS-B10985 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-PPP4C antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10985 dilution 1:50.

Anti-PPP4C Antibody (aa160-189) - LS-C162094 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PPP4C Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human prostate tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PPP4C Antibody (aa294-307) IHC-plus™ - LS-B752 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PPP4C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B752 concentration 10 ug/ml.
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