| Gene Symbol | GCDH |
|---|---|
| Entrez Gene | 2639 |
| Alt Symbol | ACAD5, GCD |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutaryl-CoA dehydrogenase |
| Other Description | glutaryl-CoA dehydrogenase, mitochondrial|glutaryl-Coenzyme A dehydrogenase |
| Swissprots | O14719 A8K2Z2 Q92947 |
| Accessions | AAB51174 AAC52079 AER00473 EAW84324 EAW84325 EAW84326 Q92947 AK098370 AK290407 BAF83096 AK296446 BAG59097 AK298772 BAG60914 AK300841 BAG62492 AK309892 AU135567 BC002579 AAH02579 BM855466 BT006706 AAP35352 DA286320 S77773 AAB34724 U69141 AAB08455 XM_006722721 XP_006722784 XM_011527899 XP_011526201 XM_011527900 XP_011526202 NM_000159 NP_000150 NM_013976 NP_039663 NR_102316 NR_102317 |
| Function | Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. {ECO:0000269|PubMed:17176108, ECO:0000269|PubMed:6423663, ECO:0000269|PubMed:8541831}. |
| Subcellular Location | Mitochondrion matrix. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in fibroblasts and liver. |
| Top Pathways | Lysine degradation, Fatty acid degradation, Tryptophan metabolism |