| Gene Symbol |
KCNMB1
|
| Entrez Gene |
3779
|
| Alt Symbol |
BKbeta1, K(VCA)beta, SLO-BETA, hbeta1, hslo-beta, k(VCA)beta-1, slo-beta-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel subfamily M regulatory beta subunit 1
|
| Other Description |
BK channel beta subunit 1|BK channel subunit beta-1|MaxiK channel beta-subunit 1|big potassium channel beta subunit 1|calcium-activated potassium channel subunit beta-1|calcium-activated potassium channel, subfamily M subunit beta-1|charybdotoxin receptor subunit beta-1|large conductance Ca2+-activated K+ channel beta 1 subunit|maxi K channel subunit beta-1|potassium large conductance calcium-activated channel, subfamily M, beta member 1
|
| Swissprots |
Q8TAX3 P78475 Q16558 Q53YR0 Q93005 O00708 O00707
|
| Accessions |
AAB16825 AAB16826 AAB39373 AAB61397 EAW61474 EAW61475 EAW61476 Q16558 AA464625 AF026002 AAB88805 AK313979 BAG36693 AY044441 AAK95827 AY515264 AAS20193 BC025707 AAH25707 DA619309 U25138 AAB02394 U38907 AAA81327 U42600 AAB16827 U61536 AAB61396 NM_004137 NP_004128
|
| Function |
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
|
| Top Pathways |
Vascular smooth muscle contraction, cGMP-PKG signaling pathway
|
