KCNMB1

Gene Symbol KCNMB1
Entrez Gene 3779
Alt Symbol BKbeta1, K(VCA)beta, SLO-BETA, hbeta1, hslo-beta, k(VCA)beta-1, slo-beta-1
Species Human
Gene Type protein-coding
Description potassium channel subfamily M regulatory beta subunit 1
Other Description BK channel beta subunit 1|BK channel subunit beta-1|MaxiK channel beta-subunit 1|big potassium channel beta subunit 1|calcium-activated potassium channel subunit beta-1|calcium-activated potassium channel, subfamily M subunit beta-1|charybdotoxin receptor subunit beta-1|large conductance Ca2+-activated K+ channel beta 1 subunit|maxi K channel subunit beta-1|potassium large conductance calcium-activated channel, subfamily M, beta member 1
Swissprots Q8TAX3 P78475 Q16558 Q53YR0 Q93005 O00708 O00707
Accessions AAB16825 AAB16826 AAB39373 AAB61397 EAW61474 EAW61475 EAW61476 Q16558 AA464625 AF026002 AAB88805 AK313979 BAG36693 AY044441 AAK95827 AY515264 AAS20193 BC025707 AAH25707 DA619309 U25138 AAB02394 U38907 AAA81327 U42600 AAB16827 U61536 AAB61396 NM_004137 NP_004128
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
Top Pathways Vascular smooth muscle contraction, cGMP-PKG signaling pathway

MaxiKβ (FL-191) - sc-33608 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MaxiKβ (Y-17) - sc-14751 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MaxiKβ (Y-17): sc-14751. Western blot analysis of MaxiKβ expression in HISM whole cell lysate.

MaxiKβ (N-15) - sc-14749 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MaxiKβ Antibody (N-15): sc-14749. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

Anti-Maxi Potassium channel beta antibody - ab3587 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Observed band size : 32 kDa (why is the actual band size different from the predicted?)This image is courtesy of an Abreview submitted by Dr Soledad Miranda-RottmannSee Abreview

Anti-Maxi Potassium channel beta antibody - ab83933 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Maxi Potassium channel beta antibody - ab154421 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Maxi Potassium channel beta antibody (ab154421) at 1/10000 dilution + Mouse heart whole cell lysate at 50 µg

Anti-KCNMB1 Antibody (aa119-133) - LS-C3256 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNMB1 Antibody (aa43-72, APC) - LS-C260953 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNMB1 Antibody (aa43-72, Azide-free, HRP) - LS-C260958 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNMB1 Antibody (aa43-72, Biotin) - LS-C260951 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNMB1 Antibody (aa43-72, PE) - LS-C260957 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNMB1 Antibody (aa43-72, AP) - LS-C260955 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNMB1 Antibody (aa43-72, FITC) - LS-C260956 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNMB1 Antibody (aa42-72) - LS-C322402 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNMB1 Antibody (aa43-72) - LS-C165443 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
KCNMB1 Antibody western blot of A549 cell line lysates (35 ug/lane). The KCNMB1 antibody detected the KCNMB1 protein (arrow).

Maxi Potassium channel beta Antibody - NB300-535 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Maxi Potassium channel beta Antibody [NB300-535] - Analysis of Maxi K+ Beta (KCNMB1) was performed by loading 20ug of Movas whole cell lysates with and without Maxi K+ Beta (KCNMB1) siRNA and 10ul prestained protein ladder per well onto a 4-20% Tris-Glycine polyacrylamide gel. Proteins were transferred to a nitrocellulose membrane and blocked with 5% Milk/TBST for at least 1 hour at room temperature. Maxi K+ Beta was detected using a Maxi K+ Beta rabbit polyclonal antibody at a concentration of 1ug/ml in blocking buffer overnight at 4 degrees C on a rocking platform, followed by a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5,000 for at least 1 hour at room temperature. Chemiluminescent detection was performed.

Maxi Potassium channel beta Antibody - NBP1-33484 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 12% SDS PAGE; antibody diluted at 1:1000.

Maxi Potassium channel beta Antibody - NBP1-19811 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Maxi Potassium channel beta Antibody [NBP1-19811] - Paraffin-embedded human brain tissue.

KCNMB1 Polyclonal Antibody - bs-7689R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNMB1 antibody produced in rabbit - SAB2700883 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KCNMB1: <B>Cat. No. SAB2700883</B>: Western Blot analysis of KCNMB1 in extracts from <B>Lanes</B><BR/>A. A431 <BR/>B. H1299 using <B>Cat. No. SAB2700883</B> at a 1:1000 dilution.

Anti-KCNMB1 antibody produced in rabbit - HPA020435 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KCNMB1: <B>Cat. No. HPA020435</B>: Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

KCNMB1-Antibody-Center - AP14747c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
KCNMB1 Antibody (Center) (Cat. #AP14747c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KCNMB1 antibody detected the KCNMB1 protein (arrow).

KCNMB1 antibody [N1C3] - GTX105666 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-KCNMB1 antibody [N1C3] used in Western blot. GTX105666

KCNMB1 antibody - GTX23587 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

KCNMB1 Antibody - middle region (OAAB11078) - OAAB11078 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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