Gene Symbol | RBBP7 |
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Entrez Gene | 5931 |
Alt Symbol | RbAp46 |
Species | Human |
Gene Type | protein-coding |
Description | retinoblastoma binding protein 7 |
Other Description | G1/S transition control protein-binding protein RbAp46|RBBP-7|histone acetyltransferase type B subunit 2|histone-binding protein RBBP7|nucleosome-remodeling factor subunit RBAP46|retinoblastoma-binding protein 7|retinoblastoma-binding protein RbAp46|retinoblastoma-binding protein p46 |
Swissprots | Q5JP00 Q16576 |
Accessions | EAW98919 EAW98920 EAW98921 Q16576 AK091911 BAG52439 AK127332 AK291567 BAF84256 AK310309 BC114500 AAI14501 BC114501 AAI14502 BQ775345 CN414343 CR541701 CAG46502 DA924163 DB460068 U35143 AAC50231 X72841 CAA51360 XM_011545553 XP_011543855 XM_011545554 XP_011543856 NM_001198719 NP_001185648 NM_002893 NP_002884 |
Function | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654}. |
Subcellular Location | Nucleus. |
RbAp46 CRISPR/Cas9 KO Plasmid (h) - sc-405076 from Santa Cruz Biotechnology
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RbAp46 HDR Plasmid (h) - sc-405076-HDR from Santa Cruz Biotechnology
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RbAp46 Double Nickase Plasmid (h) - sc-405076-NIC from Santa Cruz Biotechnology
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RbAp46 Double Nickase Plasmid (h2) - sc-405076-NIC-2 from Santa Cruz Biotechnology
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RbAp46 CRISPR Activation Plasmid (h) - sc-405076-ACT from Santa Cruz Biotechnology
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RbAp46 CRISPR Activation Plasmid (h2) - sc-405076-ACT-2 from Santa Cruz Biotechnology
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RbAp46 Lentiviral Activation Particles (h) - sc-405076-LAC from Santa Cruz Biotechnology
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RbAp46 Lentiviral Activation Particles (h2) - sc-405076-LAC-2 from Santa Cruz Biotechnology
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RbAp46 siRNA (h) - sc-37960 from Santa Cruz Biotechnology
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RbAp46 shRNA Plasmid (h) - sc-37960-SH from Santa Cruz Biotechnology
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RbAp46 shRNA (h) Lentiviral Particles - sc-37960-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU021651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1514 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1515 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1514 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1515 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03458 from Sigma-Aldrich
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RBBP7 siRNA (Human) - CRH4017 from Cohesion Biosciences
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RBBP7 - MBS828216 from MyBioSource
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RBBP7 shRNA Plasmid (Human) - CHH4017 from Cohesion Biosciences
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RBBP7 miRNA 3'UTR clone - MiUTR3H-02946 from Creative biogene
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