| Gene Symbol | RBBP7 |
|---|---|
| Entrez Gene | 5931 |
| Alt Symbol | RbAp46 |
| Species | Human |
| Gene Type | protein-coding |
| Description | retinoblastoma binding protein 7 |
| Other Description | G1/S transition control protein-binding protein RbAp46|RBBP-7|histone acetyltransferase type B subunit 2|histone-binding protein RBBP7|nucleosome-remodeling factor subunit RBAP46|retinoblastoma-binding protein 7|retinoblastoma-binding protein RbAp46|retinoblastoma-binding protein p46 |
| Swissprots | Q5JP00 Q16576 |
| Accessions | EAW98919 EAW98920 EAW98921 Q16576 AK091911 BAG52439 AK127332 AK291567 BAF84256 AK310309 BC114500 AAI14501 BC114501 AAI14502 BQ775345 CN414343 CR541701 CAG46502 DA924163 DB460068 U35143 AAC50231 X72841 CAA51360 XM_011545553 XP_011543855 XM_011545554 XP_011543856 NM_001198719 NP_001185648 NM_002893 NP_002884 |
| Function | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654}. |
| Subcellular Location | Nucleus. |