TNNT2

Gene Symbol	TNNT2
Entrez Gene	7139
Alt Symbol	CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT
Species	Human
Gene Type	protein-coding
Description	troponin T type 2 (cardiac)
Other Description	cardiomyopathy, dilated 1D (autosomal dominant)|cardiomyopathy, hypertrophic 2|troponin T, cardiac muscle|troponin T2, cardiac
Swissprots	Q99596 Q99597 Q9UM96 A8K3K6 O60214 A2TDB9 Q9BUF6 P45379
Accessions	AAB30957 AAC39590 AAK92231 AAN71650 AAN71651 ABN05286 ABR09217 ABV48784 ABV48785 ABV48786 CAA70839 CAA70840 CAA70841 EAW91353 EAW91354 EAW91355 EAW91356 EAW91357 EAW91358 EAW91359 EAW91360 EAW91361 EAW91362 P45379 AA865519 AJ709280 AK055533 AK125236 AK290621 BAF83310 AK309493 AL832707 AY277394 AAP96757 BC002653 AAH02653 HQ447413 ADQ31899 L40162 AAA67422 S64668 AAB27731 S71125 AAD14076 S71126 AAB30956 X74819 CAA52818 X79855 CAA56235 X79856 CAA56236 X79858 CAA56238 X79859 CAA56239 X79861 CAA56240 X83743 X83744 XM_006711508 XP_006711571 XM_006711509 XP_006711572 XM_011509938 XP_011508240 XM_011509939 XP_011508241 XM_011509940 XP_011508242 XM_011509941 XP_011508243 XM_011509942 XP_011508244 XM_011509943 XP_011508245 XM_011509944 XP_011508246 XM_011509945 XP_011508247 XM_011509946 XP_011508248 NM_000364 NP_000355 NM_001001430 NP_001001430 NM_001001431 NP_001001431 NM_001001432 NP_001001432 NM_001276345 NP_001263274 NM_001276346 NP_001263275 NM_001276347 NP_001263276
Function	Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Tissue Specificity	Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.
Top Pathways	Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Troponin T-C CRISPR/Cas9 KO Plasmid (h) - sc-400949 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Troponin T-C HDR Plasmid (h) - sc-400949-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Troponin T-C Double Nickase Plasmid (h) - sc-400949-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Troponin T-C Double Nickase Plasmid (h2) - sc-400949-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Troponin T-C CRISPR Activation Plasmid (h) - sc-400949-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Troponin T-C CRISPR Activation Plasmid (h2) - sc-400949-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Troponin T-C Lentiviral Activation Particles (h) - sc-400949-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Troponin T-C Lentiviral Activation Particles (h2) - sc-400949-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Troponin T-C siRNA (h) - sc-36740 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Troponin T-C shRNA Plasmid (h) - sc-36740-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Troponin T-C shRNA (h) Lentiviral Particles - sc-36740-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Troponin T Type 2 (cardiac) RNAi - H00007139-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Troponin T Type 2 (cardiac) RNAi - H00007139-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Troponin T Type 2 (cardiac) RNAi - H00007139-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU123401 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21789 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21789 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00577 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00577

TNNT2 siRNA (Human) - CRH4898 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Troponin T Type 2 (cardiac) RNAi - H00007139-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TNNT2 - MBS8204320 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Troponin T-C CRISPR/Cas9 KO Plasmid (h2) - sc-400949-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Troponin T-C HDR Plasmid (h2) - sc-400949-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human TNNT2 (NM_000364.2) - SHH432428 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TNNT2(NM_001001430.1) - SHL043428 from Creative biogene Category siRNA Species Reactivities Human

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