Gene Symbol | SCD |
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Entrez Gene | 6319 |
Alt Symbol | FADS5, MSTP008, SCD1, SCDOS |
Species | Human |
Gene Type | protein-coding |
Description | stearoyl-CoA desaturase (delta-9-desaturase) |
Other Description | acyl-CoA desaturase|delta(9)-desaturase|delta-9 desaturase|delta-9-desaturase|fatty acid desaturase|predicted protein of HQ0998|stearoyl-CoA desaturase opposite strand |
Swissprots | Q16150 D3DR68 Q5W037 O00767 Q5W038 Q96KF6 Q6GSS4 Q9BS07 Q9Y695 B2R5U0 Q53GR9 |
Accessions | AAK54510 EAW49827 EAW49828 EAW49829 EAW49830 O00767 AB032261 BAA93510 AB208982 BAD92219 AF097514 AAD29870 AF109362 AAQ13510 AI740935 AK222862 BAD96582 AK312312 BAG35237 BC005807 AAH05807 BC062303 AAH62303 BI827092 BM546583 BU940035 CD245516 CF454075 S70284 AAB30631 Y13647 CAA73998 NM_005063 NP_005054 |
Function | Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Top Pathways | PPAR signaling pathway, AMPK signaling pathway, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism |
SCD CRISPR/Cas9 KO Plasmid (h) - sc-401516 from Santa Cruz Biotechnology
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SCD HDR Plasmid (h) - sc-401516-HDR from Santa Cruz Biotechnology
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SCD Double Nickase Plasmid (h) - sc-401516-NIC from Santa Cruz Biotechnology
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SCD Double Nickase Plasmid (h2) - sc-401516-NIC-2 from Santa Cruz Biotechnology
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SCD CRISPR Activation Plasmid (h) - sc-401516-ACT from Santa Cruz Biotechnology
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SCD CRISPR Activation Plasmid (h2) - sc-401516-ACT-2 from Santa Cruz Biotechnology
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SCD Lentiviral Activation Particles (h) - sc-401516-LAC from Santa Cruz Biotechnology
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SCD Lentiviral Activation Particles (h2) - sc-401516-LAC-2 from Santa Cruz Biotechnology
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SCD siRNA (h) - sc-36464 from Santa Cruz Biotechnology
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SCD shRNA Plasmid (h) - sc-36464-SH from Santa Cruz Biotechnology
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SCD shRNA (h) Lentiviral Particles - sc-36464-V from Santa Cruz Biotechnology
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SCD-1 RNAi - H00006319-R01 from Novus Biologicals
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MISSION® esiRNA - EHU108071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18922 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18922 from Sigma-Aldrich
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SCD siRNA (Human) - CRH4257 from Cohesion Biosciences
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SCD - MBS8237188 from MyBioSource
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shRNA set against Human SCD (NM_005063.4) - SHH402468 from Creative biogene
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shRNA set against Human SCD(NM_005063.4) - SHR207276 from Creative biogene
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Human SCD siRNA - orb264759 from Biorbyt
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SCD shRNA Plasmid (Human) - CHH4257 from Cohesion Biosciences
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SCD miRNA 3'UTR clone - MiUTR1H-09162 from Creative biogene
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