Gene Symbol | CALY |
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Entrez Gene | 50632 |
Alt Symbol | DRD1IP, NSG3 |
Species | Human |
Gene Type | protein-coding |
Description | calcyon neuron-specific vesicular protein |
Other Description | D1 dopamine receptor-interacting protein|calcyon D1 dopamine receptor-interacting protein (CALCYON)|calcyon protein|dopamine receptor D1 interacting protein|neuron-specific vesicular protein calcyon |
Swissprots | Q5VWX3 Q5VWY6 Q9NYX4 Q5VWY5 |
Accessions | EAW61334 EAW61335 Q9NYX4 AF225903 AAF34714 BC038978 AAH38978 BI914942 BP392207 HG503392 XM_005252685 XP_005252742 XM_011539835 XP_011538137 XM_011539836 XP_011538138 XM_011539837 XP_011538139 XM_011539838 XP_011538140 XM_011539839 XP_011538141 NM_015722 NP_056537 |
Function | Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. {ECO:0000269|PubMed:16595675}. |
Subcellular Location | Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. |
Tissue Specificity | Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non- schizophrenics. {ECO:0000269|PubMed:12622665}. |
Top Pathways | Dopaminergic synapse |
Calcyon CRISPR/Cas9 KO Plasmid (h) - sc-408223 from Santa Cruz Biotechnology
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Calcyon HDR Plasmid (h) - sc-408223-HDR from Santa Cruz Biotechnology
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Calcyon Double Nickase Plasmid (h) - sc-408223-NIC from Santa Cruz Biotechnology
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Calcyon Double Nickase Plasmid (h2) - sc-408223-NIC-2 from Santa Cruz Biotechnology
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Calcyon CRISPR Activation Plasmid (h) - sc-408223-ACT from Santa Cruz Biotechnology
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Calcyon CRISPR Activation Plasmid (h2) - sc-408223-ACT-2 from Santa Cruz Biotechnology
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Calcyon Lentiviral Activation Particles (h) - sc-408223-LAC from Santa Cruz Biotechnology
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Calcyon Lentiviral Activation Particles (h2) - sc-408223-LAC-2 from Santa Cruz Biotechnology
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Calcyon siRNA (h) - sc-43656 from Santa Cruz Biotechnology
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Calcyon shRNA Plasmid (h) - sc-43656-SH from Santa Cruz Biotechnology
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Calcyon shRNA (h) Lentiviral Particles - sc-43656-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU138281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5311 from Sigma-Aldrich
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CALY siRNA (Human) - CRH9395 from Cohesion Biosciences
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CALY - MBS8235564 from MyBioSource
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shRNA set against Human CALY (NM_015722.3) - SHH253941 from Creative biogene
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CALY shRNA Plasmid (Human) - CHH9395 from Cohesion Biosciences
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CALY miRNA 3'UTR clone - MiUTR1H-02994 from Creative biogene
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