Gene Symbol | NKD1 |
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Entrez Gene | 85407 |
Alt Symbol | Naked1 |
Species | Human |
Gene Type | protein-coding |
Description | naked cuticle homolog 1 (Drosophila) |
Other Description | Dvl-binding protein|naked cuticle-1|naked-1|protein naked cuticle homolog 1 |
Swissprots | B2RC39 Q969G9 Q8WZ08 |
Accessions | EAW82761 Q969G9 AB062886 BAB70500 AF289584 AAL55768 AF358135 AAK57484 AK000276 AK021701 AK023784 AK314930 BAG37436 AY061883 AAL32374 BC051288 AAH51288 HG508049 XM_011523399 XP_011521701 XM_011523400 XP_011521702 XM_011523401 XP_011521703 NM_033119 NP_149110 |
Function | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}. |
Subcellular Location | Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen. {ECO:0000269|PubMed:11604995}. |
Top Pathways | Wnt signaling pathway, Hippo signaling pathway |
NKD1 CRISPR/Cas9 KO Plasmid (h) - sc-406642 from Santa Cruz Biotechnology
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NKD1 HDR Plasmid (h) - sc-406642-HDR from Santa Cruz Biotechnology
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NKD1 Double Nickase Plasmid (h) - sc-406642-NIC from Santa Cruz Biotechnology
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NKD1 Double Nickase Plasmid (h2) - sc-406642-NIC-2 from Santa Cruz Biotechnology
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NKD1 CRISPR Activation Plasmid (h) - sc-406642-ACT from Santa Cruz Biotechnology
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NKD1 CRISPR Activation Plasmid (h2) - sc-406642-ACT-2 from Santa Cruz Biotechnology
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NKD1 Lentiviral Activation Particles (h) - sc-406642-LAC from Santa Cruz Biotechnology
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NKD1 Lentiviral Activation Particles (h2) - sc-406642-LAC-2 from Santa Cruz Biotechnology
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NKD1 siRNA (h) - sc-93414 from Santa Cruz Biotechnology
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NKD1 shRNA Plasmid (h) - sc-93414-SH from Santa Cruz Biotechnology
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NKD1 shRNA (h) Lentiviral Particles - sc-93414-V from Santa Cruz Biotechnology
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NKD1 RNAi - H00085407-R01 from Novus Biologicals
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MISSION® esiRNA - EHU160011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15320 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15320 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12440 from Sigma-Aldrich
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NKD1 siRNA (Human) - CRJ3799 from Cohesion Biosciences
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NKD1 CRISPR/Cas9 KO Plasmid (h2) - sc-406642-KO-2 from Santa Cruz Biotechnology
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NKD1 HDR Plasmid (h2) - sc-406642-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human NKD1 (NM_033119.4) - SHH352692 from Creative biogene
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NKD1 shRNA Plasmid (Human) - CHJ3799 from Cohesion Biosciences
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