| Gene Symbol | CD80 |
|---|---|
| Entrez Gene | 941 |
| Alt Symbol | B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD80 molecule |
| Other Description | B-lymphocyte activation antigen B7|CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)|CTLA-4 counter-receptor B7.1|T-lymphocyte activation antigen CD80|activation B7-1 antigen|costimulatory factor CD80|costimulatory molecule variant IgV-CD80 |
| Swissprots | P33681 Q5DTB0 Q5DTA9 |
| Accessions | AAA58390 AAC51754 ABK41933 EAW79564 EAW79565 P33681 AK292129 BAF84818 AY081815 AAL89819 AY197777 AAO39208 AY197778 AAO39209 BC042665 AAH42665 BP225173 M27533 AAA36045 XM_011513325 XP_011511627 XM_011513326 XP_011511628 XM_011513327 XP_011511629 NM_005191 NP_005182 |
| Function | Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. {ECO:0000269|PubMed:10583602}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed on activated B-cells, macrophages and dendritic cells. |
| Top Pathways | Toll-like receptor signaling pathway, Type I diabetes mellitus, Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease |