Gene Symbol | Slc2a4 |
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Entrez Gene | 20528 |
Alt Symbol | Glut-4, Glut4 |
Species | Mouse |
Gene Type | protein-coding |
Description | solute carrier family 2 (facilitated glucose transporter), member 4 |
Other Description | GT2|glucose transporter type 4, insulin-responsive|solute carrier family 2, facilitated glucose transporter member 4 |
Swissprots | P14142 Q3TPK6 Q9JJN9 |
Accessions | AAX90627 CAL48833 EDL12493 EDL12494 EDL12495 EDL12496 EDL12497 P14142 AB008453 BAB03251 AK137607 BAE23429 AK138832 AK160882 AK164310 BAE37730 BC014282 AAH14282 M23383 AAA37753 XM_006532653 XP_006532716 XM_006532654 XP_006532717 XM_006532655 XP_006532718 XM_006537144 XP_006537207 XM_006537145 XP_006537208 XM_006537146 XP_006537209 XM_011248839 XP_011247141 XM_011251265 XP_011249567 NM_009204 NP_033230 |
Function | Insulin-regulated facilitative glucose transporter. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:21907143}; Multi-pass membrane protein {ECO:0000269|PubMed:21907143}. Endomembrane system {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration (By similarity). {ECO:0000250}. |
Tissue Specificity | Skeletal and cardiac muscles; brown and white fat. |
Top Pathways | Insulin signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, AMPK signaling pathway |
Glut4 CRISPR/Cas9 KO Plasmid (m) - sc-423001 from Santa Cruz Biotechnology
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Glut4 HDR Plasmid (m) - sc-423001-HDR from Santa Cruz Biotechnology
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Glut4 Double Nickase Plasmid (m) - sc-423001-NIC from Santa Cruz Biotechnology
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Glut4 Double Nickase Plasmid (m2) - sc-423001-NIC-2 from Santa Cruz Biotechnology
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Glut4 CRISPR Activation Plasmid (m) - sc-423001-ACT from Santa Cruz Biotechnology
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Glut4 CRISPR Activation Plasmid (m2) - sc-423001-ACT-2 from Santa Cruz Biotechnology
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Glut4 Lentiviral Activation Particles (m) - sc-423001-LAC from Santa Cruz Biotechnology
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Glut4 Lentiviral Activation Particles (m2) - sc-423001-LAC-2 from Santa Cruz Biotechnology
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Glut4 siRNA (m) - sc-41221 from Santa Cruz Biotechnology
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Glut4 shRNA Plasmid (m) - sc-41221-SH from Santa Cruz Biotechnology
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Glut4 shRNA (m) Lentiviral Particles - sc-41221-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU086551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN41413 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41413 from Sigma-Aldrich
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SLC2A4 siRNA (Mouse) - CRM3778 from Cohesion Biosciences
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SLC2A4 - MBS8234346 from MyBioSource
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shRNA set against Mouse SLC2A4 (NM_009204.2) - SHH410280 from Creative biogene
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shRNA set against Mouse Slc2a4(NM_009204.2) - SHL005772 from Creative biogene
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Mouse SLC2A4 siRNA - orb283254 from Biorbyt
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SLC2A4 shRNA Plasmid (Mouse) - CHM3778 from Cohesion Biosciences
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SLC2A4 miRNA 3'UTR clone - MiUTR1M-10841 from Creative biogene
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