| Gene Symbol | Slc2a4 |
|---|---|
| Entrez Gene | 20528 |
| Alt Symbol | Glut-4, Glut4 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | solute carrier family 2 (facilitated glucose transporter), member 4 |
| Other Description | GT2|glucose transporter type 4, insulin-responsive|solute carrier family 2, facilitated glucose transporter member 4 |
| Swissprots | P14142 Q3TPK6 Q9JJN9 |
| Accessions | AAX90627 CAL48833 EDL12493 EDL12494 EDL12495 EDL12496 EDL12497 P14142 AB008453 BAB03251 AK137607 BAE23429 AK138832 AK160882 AK164310 BAE37730 BC014282 AAH14282 M23383 AAA37753 XM_006532653 XP_006532716 XM_006532654 XP_006532717 XM_006532655 XP_006532718 XM_006537144 XP_006537207 XM_006537145 XP_006537208 XM_006537146 XP_006537209 XM_011248839 XP_011247141 XM_011251265 XP_011249567 NM_009204 NP_033230 |
| Function | Insulin-regulated facilitative glucose transporter. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:21907143}; Multi-pass membrane protein {ECO:0000269|PubMed:21907143}. Endomembrane system {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration (By similarity). {ECO:0000250}. |
| Tissue Specificity | Skeletal and cardiac muscles; brown and white fat. |
| Top Pathways | Insulin signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, AMPK signaling pathway |