UBE2D1

Gene Symbol	UBE2D1
Entrez Gene	7321
Alt Symbol	E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2D 1
Other Description	UBC4/5 homolog|stimulator of Fe transport|ubiquitin carrier protein D1|ubiquitin-conjugating enzyme E2 D1|ubiquitin-conjugating enzyme E2(17)KB 1|ubiquitin-conjugating enzyme E2-17 kDa 1|ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)|ubiquitin-protein ligase D1
Swissprots	A8K786 P51668 A6NLF6
Accessions	CAC82097 EAW54167 EAW54168 EAW54169 EAW54170 P51668 AF020761 AF257220 AAM81086 AI566662 AJ272367 CAC82177 AK291901 BAF84590 BC005980 AAH05980 BC015997 AAH15997 BI598342 BM468116 BM970335 BT007041 AAP35690 DA618122 DA677507 DQ893111 ABM84037 DQ896385 ABM87384 X78140 CAA55019 NM_001204880 NP_001191809 NM_003338 NP_003329
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. {ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18845142}.
Tissue Specificity	Ubiquitous. Up-regulated in livers of iron- overloaded patients with hereditary hemochromatosis. {ECO:0000269|PubMed:12480712, ECO:0000269|PubMed:9362508}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBE2D1 full length protein - ab139633 from Abcam Category Protein Source E. coli Species Human

Human UBE2D1 full length protein - ab90023 from Abcam Category Protein Source E. coli Species Human

Human UBE2D1 full length protein - ab111457 from Abcam Category Protein Source E. coli Species Human

Human UBE2D1 full length protein (tagged) - Chemical Free - ab81577 from Abcam Category Protein Source E. coli Species Human

Human UBE2D1 full length protein (Tagged) - Chemical Free - ab81580 from Abcam Category Protein Source E. coli Species Human

UBE2D1 peptide - ab86621 from Abcam Category Peptide

UBE2D1 / UBCH5 Antibody Blocking Peptide - LS-E6860 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2D1 / UBCH5 Antibody Blocking Peptide - LS-E15710 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UbcH5a/UBE2D1 Partial Recombinant Protein - H00007321-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UbcH5a/UBE2D1 Recombinant Protein - H00007321-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UbcH5a/UBE2D1 Protein - NBP1-99189 from Novus Biologicals Category Protein Prices $145.00 Sizes 10 µg Source E. coli Species Human

UbcH5a/UBE2D1 Protein - NBP1-99627 from Novus Biologicals Category Protein Species Human

Recombinant Human UbcH5a/UBE2D1 Protein - NBP1-72320 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

UbcH5a/UBE2D1 Peptide - P0883 from Novus Biologicals Category Peptide Species Human

UBE2D1-Antibody-C-term-Blocking-Peptide - BP2112b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2D1 Protein - GTX109257-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Recombinant Human UbcH5a/UBE2D1, CF - E2-616-050 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human UbcH5a/UBE2D1, CF - E2-616-100 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human GST-UbcH5a/UBE2D1, CF - E2-615-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal GST (glutathione S-transferase) tag

Recombinant Human GST-UbcH5a/UBE2D1, CF - E2-615-100 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal GST (glutathione S-transferase) tag

Recombinant Human UbcH5a/UBE2D1 - Ubiquitin Charged - E2-800-100 from R&D Systems Category Protein Source E. coli-derived,

UBE2D1 Protein (OPPA00012) - OPPA00012 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human UBE2D1 protein - orb169503 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human UBE2D1 His tag protein - orb84755 from Biorbyt Category Protein Prices $238.00, $298.00, $340.00 Sizes 50 μg, 100 μg, 200 μg Source E. coli Species Human

UBE2D1 Blocking Peptide - 33R-8734 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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