| Gene Symbol |
Prmt1
|
| Entrez Gene |
15469
|
| Alt Symbol |
6720434D09Rik, AW214366, Hrmt1l2, Mrmt1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
protein arginine N-methyltransferase 1
|
| Other Description |
arginine N-methyltransferase 1|heterogeneous nuclear ribonucleoproteins methyltransferase-like 2|histone-arginine N-methyltransferase PRMT1
|
| Swissprots |
Q9JIF0 Q99LS4
|
| Accessions |
AAF37294 EDL22776 EDL22777 EDL22778 EDL22779 Q9JIF0 AF232716 AAF37292 AF232717 AAF37293 AI846916 AK020120 BAB32002 AK088790 BAC40573 AK146927 BAE27538 AK146975 AK152342 AK164421 BAE37781 AK179815 AK181903 AK182201 AK182363 AK198313 AK216645 AK217171 BC002249 AAH02249 BC051547 AAH51547 BC051953 AAH51953 BC062964 AAH62964 BU524421 BY760714 W49313 XM_006540640 XP_006540703 XM_011250807 XP_011249109 NM_001252476 NP_001239405 NM_001252477 NP_001239406 NM_019830 NP_062804 NR_045521
|
| Function |
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. {ECO:0000269|PubMed:15327772, ECO:0000269|PubMed:19858291}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction.
|
| Top Pathways |
Glucagon signaling pathway
|