E2F1
| Gene Symbol | E2F1 |
|---|---|
| Entrez Gene | 1869 |
| Alt Symbol | E2F-1, RBAP1, RBBP3, RBP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | E2F transcription factor 1 |
| Other Description | PBR3|PRB-binding protein E2F-1|RBAP-1|RBBP-3|retinoblastoma-associated protein 1|retinoblastoma-binding protein 3|transcription factor E2F1 |
| Swissprots | Q13143 Q92768 Q01094 |
| Accessions | AAC50719 AAD14150 AAM47604 CAM91159 CAN37617 CAY56011 CBX53852 EAW76299 EAW76300 Q01094 AF086380 BC005098 AAH05098 BC050369 AAH50369 BC058902 AAH58902 M96577 AAA35782 S49592 AAB24289 NM_005225 NP_005216 |
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000250|UniProtKB:Q61501, ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:8170954}. |
| Subcellular Location | Nucleus. |
| Top Pathways | MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma |
E2F-1 CRISPR/Cas9 KO Plasmid (h) - sc-400123 from Santa Cruz Biotechnology
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E2F-1 HDR Plasmid (h) - sc-400123-HDR from Santa Cruz Biotechnology
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E2F-1 Double Nickase Plasmid (h) - sc-400123-NIC from Santa Cruz Biotechnology
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E2F-1 Double Nickase Plasmid (h2) - sc-400123-NIC-2 from Santa Cruz Biotechnology
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E2F-1 CRISPR Activation Plasmid (h) - sc-400123-ACT from Santa Cruz Biotechnology
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E2F-1 CRISPR Activation Plasmid (h2) - sc-400123-ACT-2 from Santa Cruz Biotechnology
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E2F-1 Lentiviral Activation Particles (h) - sc-400123-LAC from Santa Cruz Biotechnology
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E2F-1 Lentiviral Activation Particles (h2) - sc-400123-LAC-2 from Santa Cruz Biotechnology
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E2F-1 siRNA (h) - sc-29297 from Santa Cruz Biotechnology
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E2F-1 shRNA Plasmid (h) - sc-29297-SH from Santa Cruz Biotechnology
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E2F-1 shRNA (h) Lentiviral Particles - sc-29297-V from Santa Cruz Biotechnology
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E2F-1 siRNA (h2) - sc-44258 from Santa Cruz Biotechnology
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E2F-1 shRNA Plasmid (h2) - sc-44258-SH from Santa Cruz Biotechnology
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E2F-1 shRNA (h2) Lentiviral Particles - sc-44258-V from Santa Cruz Biotechnology
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E2F-1 RNAi - H00001869-R01 from Novus Biologicals
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RBP3 RNAi - H00005949-R01 from Novus Biologicals
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MISSION® esiRNA - EHU070981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1384 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1383 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1384 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1383 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07630 from Sigma-Aldrich
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E2F1 siRNA (Human) - CRH1306 from Cohesion Biosciences
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E2F1 - MBS8221727 from MyBioSource
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shRNA set against Human E2F1 (NM_005225.2) - SHH282489 from Creative biogene
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