| Gene Symbol |
E2F1
|
| Entrez Gene |
1869
|
| Alt Symbol |
E2F-1, RBAP1, RBBP3, RBP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E2F transcription factor 1
|
| Other Description |
PBR3|PRB-binding protein E2F-1|RBAP-1|RBBP-3|retinoblastoma-associated protein 1|retinoblastoma-binding protein 3|transcription factor E2F1
|
| Swissprots |
Q13143 Q92768 Q01094
|
| Accessions |
AAC50719 AAD14150 AAM47604 CAM91159 CAN37617 CAY56011 CBX53852 EAW76299 EAW76300 Q01094 AF086380 BC005098 AAH05098 BC050369 AAH50369 BC058902 AAH58902 M96577 AAA35782 S49592 AAB24289 NM_005225 NP_005216
|
| Function |
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000250|UniProtKB:Q61501, ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:8170954}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma
|