Gene Symbol | MUC2 |
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Entrez Gene | 4583 |
Alt Symbol | MLP, MUC-2, SMUC |
Species | Human |
Gene Type | protein-coding |
Description | mucin 2, oligomeric mucus/gel-forming |
Other Description | intestinal mucin-2|mucin 2, intestinal/tracheal|mucin-2|mucin-like protein |
Swissprots | Q14878 Q02817 |
Accessions | AAA59875 AAC51519 AAG18515 AAG18516 EAX02421 EAX02422 Q02817 AA527400 AF257167 AAG18517 AW054915 BG982960 BQ340542 CV354692 DV080627 L21998 AAB95295 M22404 AAA36333 M22405 AAA36334 M57417 AAA63229 M86523 AAA59861 M94131 AAA59163 M94132 AAA59164 NM_002457 NP_002448 |
Function | Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. {ECO:0000269|PubMed:19432394}. |
Subcellular Location | Secreted. Note=In the intestine, secreted into the inner and outer mucus layers. {ECO:0000250}. |
Tissue Specificity | Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder. |
Top Pathways | Vibrio cholerae infection, Amoebiasis |
Mucin 2 CRISPR/Cas9 KO Plasmid (h) - sc-400221 from Santa Cruz Biotechnology
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Mucin 2 HDR Plasmid (h) - sc-400221-HDR from Santa Cruz Biotechnology
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Mucin 2 Double Nickase Plasmid (h) - sc-400221-NIC from Santa Cruz Biotechnology
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Mucin 2 Double Nickase Plasmid (h2) - sc-400221-NIC-2 from Santa Cruz Biotechnology
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Mucin 2 CRISPR Activation Plasmid (h) - sc-400221-ACT from Santa Cruz Biotechnology
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Mucin 2 CRISPR Activation Plasmid (h2) - sc-400221-ACT-2 from Santa Cruz Biotechnology
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Mucin 2 Lentiviral Activation Particles (h) - sc-400221-LAC from Santa Cruz Biotechnology
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Mucin 2 Lentiviral Activation Particles (h2) - sc-400221-LAC-2 from Santa Cruz Biotechnology
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Mucin 2 siRNA (h) - sc-43160 from Santa Cruz Biotechnology
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Mucin 2 shRNA Plasmid (h) - sc-43160-SH from Santa Cruz Biotechnology
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Mucin 2 shRNA (h) Lentiviral Particles - sc-43160-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN14756 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14756 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01113 from Sigma-Aldrich
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MUC2 siRNA (Human) - CRH3020 from Cohesion Biosciences
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MUC2 RNAi - H00004583-R01 from Novus Biologicals
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shRNA set against Human Muc2 (NM_002457.2) - SHH346892 from Creative biogene
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MUC2 shRNA Plasmid (Human) - CHH3020 from Cohesion Biosciences
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MUC2 miRNA 3'UTR clone - MiUTR1H-06530 from Creative biogene
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