| Gene Symbol |
DOC2B
|
| Entrez Gene |
8447
|
| Alt Symbol |
DOC2BL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
double C2-like domains, beta
|
| Other Description |
doc2-beta|double C2-like domain-containing protein beta
|
| Swissprots |
Q14184
|
| Accessions |
EAW90677 Q14184 AI478508 BC152720 AAI52721 BC153024 AAI53025 BM713588 D70830 BAA11107 DN831650 XM_011535363 XP_011533665 XR_942188 XR_942189 XR_942190 NM_003585 NP_003576
|
| Function |
Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Cytoplasmic granule {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the plasma membrane in a calcium-dependent manner. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level). {ECO:0000269|PubMed:17548353, ECO:0000269|PubMed:8554557}.
|