TYROBP

Gene Symbol TYROBP
Entrez Gene 7305
Alt Symbol DAP12, KARAP, PLOSL
Species Human
Gene Type protein-coding
Description TYRO protein tyrosine kinase binding protein
Other Description DNAX-activation protein 12|KAR-associated protein|TYRO protein tyrosine kinase-binding protein|killer-activating receptor-associated protein
Swissprots A8K2X0 O43914 Q6FGA5 Q9UMT3 F5H389
Accessions AAD09437 O43914 AF019562 AAD09436 AJ010098 CAB52288 AK290385 BAF83074 AY074782 AAL74017 BC011175 AAH11175 BI908458 BP295666 BP302545 BP305672 BQ576278 BT009851 AAP88853 CR450342 CAG29338 CR542202 CAG46999 DQ891092 ABM82018 DQ894274 ABM85200 NM_001173514 NP_001166985 NM_001173515 NP_001166986 NM_003332 NP_003323 NM_198125 NP_937758 NR_033390
Function Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum. {ECO:0000269|PubMed:11922939}.
Top Pathways Natural killer cell mediated cytotoxicity, Osteoclast differentiation

DAP12 (D7G1X) Rabbit mAb - 12492 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7G1X
Western blot analysis of extracts from THP-1, U-937, and Raw 264.7 cells using DAP12 (D7G1X) Rabbit mAb.

DAP12 (A-4) - sc-166084 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DAP12 (A-4): sc-166084. Western blot analysis of DAP12 expression in non-transfected: sc-117752 (A) and human DAP12 transfected: sc-112269 (B) 293T whole cell lysates.

DAP12 (A-8) - sc-166085 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DAP12 (A-8): sc-166085. Western blot analysis of DAP12 expression in non-transfected: sc-117752 (A) and human DAP12 transfected: sc-112269 (B) 293T whole cell lysates.

DAP12 (FL-113) - sc-20783 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DAP12 (FL-113): sc-20783. Western blot analysis of DAP12 expression in non-transfected: sc-117752 (A) and human DAP12 transfected: sc-112269 (B) and 293T whole cell lysates.

DAP12 (C-20) - sc-7853 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DAP12 (C-20): sc-7853. Western blot analysis of DAP12 expression in J774.A1 whole cell lysate.

DAP12 (G-5) - sc-133174 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DAP12 (G-5): sc-133174. Western blot analysis of DAP12 expression in non-transfected: sc-110760 (A) and human DAP12 transfected: sc-112269 (B) 293 whole cell lysates.

DAP12 (V-20) - sc-7854 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DAP12 (B-2) - sc-166086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DAP12 (B-2): sc-166086. Western blot analysis of DAP12 expression in non-transfected: sc-117752 (A) and human DAP12 transfected: sc-112269 (B) 293T whole cell lysates.

Anti-DAP12 antibody - ab16462 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DAP12 antibody - ab103486 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DAP12 antibody (ab103486) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-DAP12 antibody - ab25097 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DAP12 antibody (ab25097) at 1/2000 dilution + transfected cell lysate

Anti-DAP12 antibody [EPR5173] - ab124834 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5173
Overlay histogram showing THP1 cells stained with ab124834 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% human serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab124834, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-DAP12 Antibody IHC-plus™ - LS-B3718 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-TYROBP / DAP12 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3718 concentration 3 ug/ml.

Anti-DAP12 Antibody - LS-C14801 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DAP12 Antibody - LS-C14802 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DAP12 Antibody (aa84-113, AP) - LS-C272807 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAP12 Antibody (aa84-113, Biotin) - LS-C272808 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAP12 Antibody - LS-C26780 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunoprecipitation using DAP12 antibody on MHC class I (1) and NKp44 (2) positive cells.

Anti-DAP12 Antibody (aa84-113, APC) - LS-C272809 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAP12 Antibody (aa84-113, FITC) - LS-C272810 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAP12 Antibody (Internal, clone EPR5173) - LS-C138763 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5173
Western blot analysis on (A) peripheral blood leukocytes, (B) human placenta, and (C) peripheral blood mononuclear cell lysates using anti-DAP12 antibody.

Anti-DAP12 Antibody (aa84-113, Azide-free, HRP) - LS-C272811 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAP12 Antibody (aa84-113, PE) - LS-C272815 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAP12 Antibody (aa84-113) - LS-C326115 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAP12 Antibody - LS-C147133 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of DAP12 antibody LS-C147133.
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