| Gene Symbol |
HHEX
|
| Entrez Gene |
3087
|
| Alt Symbol |
HEX, HMPH, HOX11L-PEN, PRH, PRHX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hematopoietically expressed homeobox
|
| Other Description |
hematopoietically-expressed homeobox protein HHEX|homeobox protein HEX|homeobox protein PRH|homeobox, hematopoietically expressed|proline-rich homeodomain-containing transcription factor
|
| Swissprots |
B1AQ17 Q03014 Q96CE9
|
| Accessions |
AAK12833 EAW50087 EAW50088 Q03014 AA810064 AK309463 AK314891 BAG37405 BC014336 AAH14336 BC015110 AAH15110 BC050638 AAH50638 BI823658 BM543214 DB504532 EU446478 ABZ92007 L16499 AAA02988 X67235 CAA47661 Z21533 CAA79730 NM_002729 NP_002720
|
| Function |
Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Liver and promyelocytic leukemia cell line HL- 60. {ECO:0000269|PubMed:1360645, ECO:0000269|PubMed:8096636, ECO:0000269|PubMed:8103988}.
|
| Top Pathways |
Maturity onset diabetes of the young, Transcriptional misregulation in cancer
|